Oxcarbazepine
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Reactions 1266 - 22 Aug 2009 S Oxcarbazepine Stevens-Johnson syndrome: case report A 53-year-old man with epilepsy, whose seizures were inadequately controlled on valproic acid, started receiving oxcarbazepine [dosage not stated] on 9 July 2007. On 20 July, he developed a sore throat, injected eyes and lip erosions; high fever and erythematous skin rashes appeared the following day. On presentation, widespread, confluent erythematous macules and papules, and numerous flat atypical targetoid lesions were evident on his face, neck, trunk and proximal upper extremities. Other findings included diffuse oral erosions and bilateral conjunctivitis. Stevens-Johnson syndrome was diagnosed. An oxcarbazepine-induced reaction was suspected, and genotyping then revealed the presence of the HLA-B*1502 allele. [Treatment and outcome not stated.] Chen Y-C, et al. Oxcarbazepine-induced Stevens-Johnson syndrome in a patient with HLA-B*1502 genotype. Journal of the European Academy of Dermatology and Venereology 23: 702-703, No. 6, Jun 2009 - Taiwan 801150046 1 Reactions 22 Aug 2009 No. 1266 0114-9954/10/1266-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Oxcarbazepine
Reactions 1266 - 22 Aug 2009
SOxcarbazepine
Stevens-Johnson syndrome: case reportA 53-year-old man with epilepsy, whose seizures were
inadequately controlled on valproic acid, started receivingoxcarbazepine [dosage not stated] on 9 July 2007. On20 July, he developed a sore throat, injected eyes and liperosions; high fever and erythematous skin rashesappeared the following day. On presentation, widespread,confluent erythematous macules and papules, andnumerous flat atypical targetoid lesions were evident on hisface, neck, trunk and proximal upper extremities. Otherfindings included diffuse oral erosions and bilateralconjunctivitis. Stevens-Johnson syndrome was diagnosed.An oxcarbazepine-induced reaction was suspected, andgenotyping then revealed the presence of the HLA-B*1502allele. [Treatment and outcome not stated.]Chen Y-C, et al. Oxcarbazepine-induced Stevens-Johnson syndrome in a patientwith HLA-B*1502 genotype. Journal of the European Academy of Dermatologyand Venereology 23: 702-703, No. 6, Jun 2009 - Taiwan 801150046
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Reactions 22 Aug 2009 No. 12660114-9954/10/1266-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
