Reactions 920 - 21 Sep 2002

SOxcarbazepine

Syndrome of inappropriate antidiuretic hormonesecretion in an elderly patient: case report

A 70-year-old man developed the syndrome ofinappropriate antidiuretic hormone secretion (SIADH) whilereceiving oxcarbazepine for a manic state associated withbipolar disorder.

The man had been hospitalised and was receivingoxcarbazepine 150 mg/day, gradually increased to 600 mg/dayin the third week. During the sixth week of treatment, hedeveloped weakness, lethargy, dizziness, nausea and hiccups.Laboratory investigations revealed serum sodium andpotassium levels of 106 and 4.4 mEq/L, respectively; althoughhe was on a low-sodium diet his urine sodium was 40 mEq/L.

Oxcarbazepine was discontinued and the man received IVfurosemide and isotonic saline. A normal sodium diet and fluidrestriction were initiated. A diagnosis of SIADH was made. Hisserum sodium levels gradually increased to normal valueswithin 1 week and lithium treatment was started. During a4-month follow-up period, hyponatraemia did not recur.Cilli AS, et al. Oxcarbazepine-induced syndrome of inappropriate secretion ofantidiuretic hormone. Journal of Clinical Psychiatry 63: 742, Aug 2002 -Turkey 800917412

1

Reactions 21 Sep 2002 No. 9200114-9954/10/0920-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved