Oxcarbazepine
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Reactions 920 - 21 Sep 2002 S Oxcarbazepine Syndrome of inappropriate antidiuretic hormone secretion in an elderly patient: case report A 70-year-old man developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH) while receiving oxcarbazepine for a manic state associated with bipolar disorder. The man had been hospitalised and was receiving oxcarbazepine 150 mg/day, gradually increased to 600 mg/day in the third week. During the sixth week of treatment, he developed weakness, lethargy, dizziness, nausea and hiccups. Laboratory investigations revealed serum sodium and potassium levels of 106 and 4.4 mEq/L, respectively; although he was on a low-sodium diet his urine sodium was 40 mEq/L. Oxcarbazepine was discontinued and the man received IV furosemide and isotonic saline. A normal sodium diet and fluid restriction were initiated. A diagnosis of SIADH was made. His serum sodium levels gradually increased to normal values within 1 week and lithium treatment was started. During a 4-month follow-up period, hyponatraemia did not recur. Cilli AS, et al. Oxcarbazepine-induced syndrome of inappropriate secretion of antidiuretic hormone. Journal of Clinical Psychiatry 63: 742, Aug 2002 - Turkey 800917412 1 Reactions 21 Sep 2002 No. 920 0114-9954/10/0920-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Oxcarbazepine
Reactions 920 - 21 Sep 2002
SOxcarbazepine
Syndrome of inappropriate antidiuretic hormonesecretion in an elderly patient: case report
A 70-year-old man developed the syndrome ofinappropriate antidiuretic hormone secretion (SIADH) whilereceiving oxcarbazepine for a manic state associated withbipolar disorder.
The man had been hospitalised and was receivingoxcarbazepine 150 mg/day, gradually increased to 600 mg/dayin the third week. During the sixth week of treatment, hedeveloped weakness, lethargy, dizziness, nausea and hiccups.Laboratory investigations revealed serum sodium andpotassium levels of 106 and 4.4 mEq/L, respectively; althoughhe was on a low-sodium diet his urine sodium was 40 mEq/L.
Oxcarbazepine was discontinued and the man received IVfurosemide and isotonic saline. A normal sodium diet and fluidrestriction were initiated. A diagnosis of SIADH was made. Hisserum sodium levels gradually increased to normal valueswithin 1 week and lithium treatment was started. During a4-month follow-up period, hyponatraemia did not recur.Cilli AS, et al. Oxcarbazepine-induced syndrome of inappropriate secretion ofantidiuretic hormone. Journal of Clinical Psychiatry 63: 742, Aug 2002 -Turkey 800917412
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Reactions 21 Sep 2002 No. 9200114-9954/10/0920-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
