Lorazepam Pancytopenia: case report

A course of radiotherapy was started in a 47-year-old woman following treatment with hysterectomy and bilateral salpingo-oophorectomy for adenocarcinoma of the uterus. Five days earlier she had begun taking nightly doses of lorazepam 1 mg to assist in sleeping. 15 days after beginning lorazepam, pancytopenia was noted and lorazepam was withdrawn 3 days later. Blood count normalised and remained normal despite continuing radiotherapy.

Radiotherapy had been administered to the true pelvis but it was felt that it had not been a major contribution to pancytopenia (total dose of 4250 cGy in 20 fractions).

EI-Sayed S. Symonds RP Bnttsh Medtcal Journal

296. 1332. 7 May 1988

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