Oxcarbazepine
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Reactions 1508, p29 - 5 Jul 2014 Oxcarbazepine Fixed drug eruption: case report A 62-year-old man developed fixed drug eruption while receiving oxcarbazepine. The man, who had generalised idiopathic epilepsy, started receiving oxcarbazepine 150mg twice daily; his seizures were subsequently controlled at a dose of 300mg twice daily [route not stated]. One week after starting treatment, he developed a skin reaction on his left arm. The man’s oxcarbazepine dose was immediately reduced, and he started receiving topiramate. In 5 days, the skin reaction became more serious. He had an eroded erythematous plaque on his arm measuring 8cm × 5cm. He was diagnosed with fixed drug eruption, and he was prescribed mometasone. Oxcarbazepine was discontinued, and he recovered within 1 week. Author comment: "In this article, a serious skin reaction associated with [oxcarbazepine] is highlighted. . . According to the Naranjo algorithm that determines the probability of connection between drug and adverse drug reaction, the observed adverse effect is possibly connected with [oxcarbazepine]." Stuhec M. Oxcarbamazepine associated with serious skin reaction: A case report. Journal of Clinical Psychopharmacology 34: e2-e3, No. 3, Jun 2014. Available from: URL: http://doi.org/10.1097/JCP.0000000000000086 - Slovenia 803105297 1 Reactions 5 Jul 2014 No. 1508 0114-9954/14/1508-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1508, p29 - 5 Jul 2014
Oxcarbazepine
Fixed drug eruption: case reportA 62-year-old man developed fixed drug eruption while
receiving oxcarbazepine. The man, who had generalisedidiopathic epilepsy, started receiving oxcarbazepine 150mgtwice daily; his seizures were subsequently controlled at adose of 300mg twice daily [route not stated]. One week afterstarting treatment, he developed a skin reaction on his leftarm. The man’s oxcarbazepine dose was immediatelyreduced, and he started receiving topiramate. In 5 days, theskin reaction became more serious. He had an erodederythematous plaque on his arm measuring 8cm × 5cm. Hewas diagnosed with fixed drug eruption, and he wasprescribed mometasone. Oxcarbazepine was discontinued,and he recovered within 1 week.
Author comment: "In this article, a serious skin reactionassociated with [oxcarbazepine] is highlighted. . . Accordingto the Naranjo algorithm that determines the probability ofconnection between drug and adverse drug reaction, theobserved adverse effect is possibly connected with[oxcarbazepine]."Stuhec M. Oxcarbamazepine associated with serious skin reaction: A case report.Journal of Clinical Psychopharmacology 34: e2-e3, No. 3, Jun 2014. Availablefrom: URL: http://doi.org/10.1097/JCP.0000000000000086 - Slovenia 803105297
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Reactions 5 Jul 2014 No. 15080114-9954/14/1508-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
