Oxcarbazepine
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Reactions 710 - 18 Jul 1998 Oxcarbazepine Hyponatraemia in a child: case report A 12-year-old girl developed severe hyponatraemia and hypochloraemia after she was treated for 3 months with oxcarbazepine 46 mg/kg [frequency of administration not stated] and valproic acid for seizures. The patient presented with a deterioration in fine motor skills and slowed mental processes. Her serum level of 10-hydroxycarbazepine, the active metabolite of oxcarbazepine, was 95 µmol/L. An electroencephalogram (EEG) showed marked slowing of the background activity compared to a baseline EEG. Her serum sodium level was 118 mmol/L and her serum chloride level was 81 mmol/L. Oxcarbazepine was withdrawn and the girl’s electrolytes normalised rapidly. Her EEG background activity became faster, with a corresponding improvement in her mental alertness within the next 3 days. She resumed treatment with carbamazepine a few weeks later, with no further sequelae. Author comment: Children may be at risk of developing hyponatraemia during oxcarbazepine therapy and therefore sodium levels should be carefully monitored. Borusiak P, et al. Hyponatremia induced by oxcarbazepine in children. Epilepsy Research 30: 241-246, May 1998 - Germany 800688113 1 Reactions 18 Jul 1998 No. 710 0114-9954/10/0710-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 710 - 18 Jul 1998
Oxcarbazepine
Hyponatraemia in a child: case reportA 12-year-old girl developed severe hyponatraemia and
hypochloraemia after she was treated for 3 months withoxcarbazepine 46 mg/kg [frequency of administration notstated] and valproic acid for seizures.
The patient presented with a deterioration in fine motorskills and slowed mental processes. Her serum level of10-hydroxycarbazepine, the active metabolite ofoxcarbazepine, was 95 µmol/L. An electroencephalogram(EEG) showed marked slowing of the background activitycompared to a baseline EEG. Her serum sodium level was 118mmol/L and her serum chloride level was 81 mmol/L.
Oxcarbazepine was withdrawn and the girl’s electrolytesnormalised rapidly. Her EEG background activity becamefaster, with a corresponding improvement in her mentalalertness within the next 3 days. She resumed treatment withcarbamazepine a few weeks later, with no further sequelae.
Author comment: Children may be at risk of developinghyponatraemia during oxcarbazepine therapy and thereforesodium levels should be carefully monitored.Borusiak P, et al. Hyponatremia induced by oxcarbazepine in children. EpilepsyResearch 30: 241-246, May 1998 - Germany 800688113
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Reactions 18 Jul 1998 No. 7100114-9954/10/0710-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
