Carbamazepine overdose
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Reactions 1429 - 24 Nov 2012 O S Carbamazepine overdose Hyponatraemic seizure in an infant: case report A 14-month-old girl developed a hyponatraemic seizure due to carbamazepine intoxication [amount ingested and time to reaction onset not stated]. The girl was hospitalised after experiencing a generalised tonic-clonic seizure lasting up to 5 minutes. Upon admission, she was lethargic. Laboratory investigations included the following: sodium 114 mmol/L, chloride 87 mmol/L, spot urine sodium 94.56 mmol/L, urine density 1005 and haemoglobin 10.7 g/dL. Carbamazepine intoxication was suspected. It was discovered that her mother had a history of epilepsy and carbamazepine use. The girl’s carbamazepine concentration was 19.14 µg/mL. Treatment consisted of gastric lavage, activated charcoal and fluids. The girl’s level of consciousness increased, her carbamazepine concentration decreased to 5.64 µg/mL and her sodium level normalised. She recovered and was discharged. Author comment: "The treatment of CN [carbamazepine] intoxication is often an auxiliary treatment. . . Our patient has recovered by general support and limited fluid treatment." "[In] unexplained cases of poisoning in children, the drugs used by parents should be questioned." Bektas MS, et al. Hyponatremic seizure of carbamazepine poisoning. European Journal of General Medicine 9: 62-63, No. 1, Jan 2012 - Turkey 803080147 1 Reactions 24 Nov 2012 No. 1429 0114-9954/10/1429-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine overdose
Reactions 1429 - 24 Nov 2012
O SCarbamazepine overdose
Hyponatraemic seizure in an infant: case reportA 14-month-old girl developed a hyponatraemic seizure
due to carbamazepine intoxication [amount ingested andtime to reaction onset not stated].
The girl was hospitalised after experiencing a generalisedtonic-clonic seizure lasting up to 5 minutes. Uponadmission, she was lethargic. Laboratory investigationsincluded the following: sodium 114 mmol/L, chloride87 mmol/L, spot urine sodium 94.56 mmol/L, urine density1005 and haemoglobin 10.7 g/dL. Carbamazepineintoxication was suspected. It was discovered that hermother had a history of epilepsy and carbamazepine use.The girl’s carbamazepine concentration was 19.14 µg/mL.
Treatment consisted of gastric lavage, activated charcoaland fluids. The girl’s level of consciousness increased, hercarbamazepine concentration decreased to 5.64 µg/mL andher sodium level normalised. She recovered and wasdischarged.
Author comment: "The treatment of CN [carbamazepine]intoxication is often an auxiliary treatment. . . Our patient hasrecovered by general support and limited fluid treatment.""[In] unexplained cases of poisoning in children, the drugsused by parents should be questioned."Bektas MS, et al. Hyponatremic seizure of carbamazepine poisoning. EuropeanJournal of General Medicine 9: 62-63, No. 1, Jan 2012 - Turkey 803080147
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Reactions 24 Nov 2012 No. 14290114-9954/10/1429-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
