Carbamazepine
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Reactions 482 - 18 Dec 1993 S Carbamazepine Respiratory tract disorders: case report A 62-year-old man was admitted with dyspnoea following 3 months’ treatment with carbamazepine 200mg bid for arteriovenous malformation. An extensive skin eruption had developed 3 weeks after initiation of carbamazepine. All medication except carbamazepine was discontinued but the skin rash became generalised, and cough and fever developed. Crackling rales and diffuse infiltrates throughout both lungs were revealed by chest auscultation and x-ray. Skin biopsy revealed findings compatible with toxic dermatitis. A presumptive diagnosis of interstitial pneumonitis was made and carbamazepine was discontinued. The patient became afebrile and his dyspnoea improved 5 days after admission. His general condition improved gradually over the following weeks and he was discharged 11 weeks after admission. X-ray showed no abnormalities at follow-up, 3 months after discharge. Author comment: ‘We believe this case represents acute interstitial pneumonitis induced by carbamazepine. Carbamazepine should be added to the list of agents which can induce acute interstitial pneumonitis.’ Takahashi N, et al. Acute interstitial pneumonitis induced by carbamazepine. European Respiratory Journal 6: 1409-1411, Oct 1993 - Japan 800231119 1 Reactions 18 Dec 1993 No. 482 0114-9954/10/0482-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 482 - 18 Dec 1993
SCarbamazepine
Respiratory tract disorders: case reportA 62-year-old man was admitted with dyspnoea following 3
months’ treatment with carbamazepine 200mg bid forarteriovenous malformation.
An extensive skin eruption had developed 3 weeks afterinitiation of carbamazepine. All medication exceptcarbamazepine was discontinued but the skin rash becamegeneralised, and cough and fever developed. Crackling ralesand diffuse infiltrates throughout both lungs were revealed bychest auscultation and x-ray. Skin biopsy revealed findingscompatible with toxic dermatitis. A presumptive diagnosis ofinterstitial pneumonitis was made and carbamazepine wasdiscontinued. The patient became afebrile and his dyspnoeaimproved 5 days after admission. His general conditionimproved gradually over the following weeks and he wasdischarged 11 weeks after admission. X-ray showed noabnormalities at follow-up, 3 months after discharge.
Author comment: ‘We believe this case represents acuteinterstitial pneumonitis induced by carbamazepine.Carbamazepine should be added to the list of agents which caninduce acute interstitial pneumonitis.’Takahashi N, et al. Acute interstitial pneumonitis induced by carbamazepine.European Respiratory Journal 6: 1409-1411, Oct 1993 - Japan 800231119
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Reactions 18 Dec 1993 No. 4820114-9954/10/0482-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
