Carbamazepine
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Reactions 1404 - 2 Jun 2012 S Carbamazepine Toxic epidermal necrolysis with ocular involvement treated with ophthalmic ciclosporin: case report A 20-year woman developed toxic epidermal necrolysis (TEN) with ocular involvement during treatment with carbamazepine for epilepsy. Treatment of her ocular symptoms included topical ophthalmic ciclosporin. The woman presented with a 2-day history of an erythematous generalised maculopapular rash. Her epileptic medication had been switched from valproic acid to carbamazepine [route and dosage not stated] 5 days previously. Physical examination revealed vesiculobullous and maculopapular eruptions and rashes which involved > 80% of her total body surface area. Her mucous membranes were also involved. Her body temperature was 38.6°C and she was tachypneic. Ophthalmic investigation revealed bilateral pseudomembranous conjunctivitis, hyperaemic conjunctiva, and vesiculobullous skin lesions on her eyelids. Her clinical diagnosis was consistent with TEN. The woman was admitted to an ICU and her carbamazepine was immediately withdrawn. She received systemic therapy with methylprednisolone, teicoplanin, and IV immunoglobulin. Her ophthalmic treatment included ophthalmic ciclosporin 3 x 1 in addition to topical corticosteroids. Progression of her TEN was stopped on day 6 of disease onset and she was discharged on day 16. She received ophthalmic ciclosporin and a topical corticosteroid for 2 months. An ophthalmic examination at her 4-month follow-up showed normal anterior segment features and the only finding was a symblepharon in the lower fornix of her right eye. Onaran Z, et al. Topical ophthalmic cyclosporine in the treatment of toxic epidermal necrolysis. Case Reports in Medicine 2011: No. 416842, 2011. Available from: URL: http://dx.doi.org/10.1155/2011/416842 - Turkey 803071190 1 Reactions 2 Jun 2012 No. 1404 0114-9954/10/1404-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1404 - 2 Jun 2012
SCarbamazepine
Toxic epidermal necrolysis with ocularinvolvement treated with ophthalmic ciclosporin:case report
A 20-year woman developed toxic epidermal necrolysis(TEN) with ocular involvement during treatment withcarbamazepine for epilepsy. Treatment of her ocularsymptoms included topical ophthalmic ciclosporin.
The woman presented with a 2-day history of anerythematous generalised maculopapular rash. Herepileptic medication had been switched from valproic acidto carbamazepine [route and dosage not stated] 5 dayspreviously. Physical examination revealed vesiculobullousand maculopapular eruptions and rashes which involved> 80% of her total body surface area. Her mucousmembranes were also involved. Her body temperature was38.6°C and she was tachypneic. Ophthalmic investigationrevealed bilateral pseudomembranous conjunctivitis,hyperaemic conjunctiva, and vesiculobullous skin lesionson her eyelids. Her clinical diagnosis was consistent withTEN.
The woman was admitted to an ICU and hercarbamazepine was immediately withdrawn. She receivedsystemic therapy with methylprednisolone, teicoplanin,and IV immunoglobulin. Her ophthalmic treatmentincluded ophthalmic ciclosporin 3 x 1 in addition to topicalcorticosteroids. Progression of her TEN was stopped onday 6 of disease onset and she was discharged on day 16.She received ophthalmic ciclosporin and a topicalcorticosteroid for 2 months. An ophthalmic examination ather 4-month follow-up showed normal anterior segmentfeatures and the only finding was a symblepharon in thelower fornix of her right eye.Onaran Z, et al. Topical ophthalmic cyclosporine in the treatment of toxicepidermal necrolysis. Case Reports in Medicine 2011: No. 416842, 2011.Available from: URL: http://dx.doi.org/10.1155/2011/416842 - Turkey 803071190
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Reactions 2 Jun 2012 No. 14040114-9954/10/1404-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
