Carbamazepine
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Reactions 1321 - 2 Oct 2010 S Carbamazepine Stevens-Johnson syndrome and toxic epidermal necrolysis: case report A 61-year-old woman developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) during carbamazepine treatment for postherpetic neuralgia. She subsequently died. The woman started carbamazepine 300 mg/day [route not stated] in conjunction with amitriptyline and a local anaesthetic, after referral to an outpatient pain unit in August 2007. When she returned 2 weeks later, she had developed malaise, fever, muscle pain, and arthralgias with a mild and nonspecific skin rash. Carbamazepine was immediately discontinued. The woman was admitted to hospital 1 week later with symptoms of urticaria and generalised exanthema, erythematous bullous skin eruptions and purpuric macules affecting her whole body. Findings were consistent with carbamazepine-induced SJS/TEN, and she subsequently began codeine and dipyrone for pain management. Her symptoms progressed rapidly, with an increase in the size and number of skin lesions. She had a generalised erythematous rash with areas of necrosis and erosions, symmetrical epidermal sloughing on face, neck, chest and the upper and lower limbs, affecting more than 50% of the total surface area, as well as involving the oral, conjunctival and genital mucosa with painful, vesicular erosions. She was transferred to the ICU with progressively declining respiratory and cardiovascular function, and 2 weeks later developed septic shock and multiple organ failure resulting in death. Garcia JBS, et al. Severe carbamazepine-induced cutaneous reaction in the treatment of post-herpetic neuralgia. Case report. Revista Brasileira de Anestesiologia 60: 429-437, No. 4, Aug 2010. Available from: URL: http:// dx.doi.org/10.1590/s0034-70942010000400011 - Brazil 803040308 1 Reactions 2 Oct 2010 No. 1321 0114-9954/10/1321-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1321 - 2 Oct 2010
SCarbamazepine
Stevens-Johnson syndrome and toxic epidermalnecrolysis: case report
A 61-year-old woman developed Stevens-Johnsonsyndrome (SJS) and toxic epidermal necrolysis (TEN)during carbamazepine treatment for postherpeticneuralgia. She subsequently died.
The woman started carbamazepine 300 mg/day [routenot stated] in conjunction with amitriptyline and a localanaesthetic, after referral to an outpatient pain unit inAugust 2007. When she returned 2 weeks later, she haddeveloped malaise, fever, muscle pain, and arthralgias witha mild and nonspecific skin rash.
Carbamazepine was immediately discontinued. Thewoman was admitted to hospital 1 week later withsymptoms of urticaria and generalised exanthema,erythematous bullous skin eruptions and purpuric maculesaffecting her whole body. Findings were consistent withcarbamazepine-induced SJS/TEN, and she subsequentlybegan codeine and dipyrone for pain management. Hersymptoms progressed rapidly, with an increase in the sizeand number of skin lesions. She had a generalisederythematous rash with areas of necrosis and erosions,symmetrical epidermal sloughing on face, neck, chest andthe upper and lower limbs, affecting more than 50% of thetotal surface area, as well as involving the oral, conjunctivaland genital mucosa with painful, vesicular erosions. Shewas transferred to the ICU with progressively decliningrespiratory and cardiovascular function, and 2 weeks laterdeveloped septic shock and multiple organ failure resultingin death.Garcia JBS, et al. Severe carbamazepine-induced cutaneous reaction in thetreatment of post-herpetic neuralgia. Case report. Revista Brasileira deAnestesiologia 60: 429-437, No. 4, Aug 2010. Available from: URL: http://dx.doi.org/10.1590/s0034-70942010000400011 - Brazil 803040308
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Reactions 2 Oct 2010 No. 13210114-9954/10/1321-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
