Symbole graficzne aparatów, maszyn i urządzeń przemysłu chemicznego
Carbamazepine
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Reactions 872 - 6 Oct 2001 Carbamazepine Altered pitch perception in paediatric patients: 2 case reports Two paediatric patients experienced a pitch perception shift during treatment with carbamazepine. The first patient was a 17-year-old girl with a dysthymic disorder and schizoid personality traits. She had absolute pitch and played the piano. However, 2 days after she began carbamazepine 400 mg/day, sulpiride and bromazepam to control impulsive behaviour, she developed a significant change in her perception of pitch. She reported that sounds seemed to have a lower pitch by a semitone. Her pitch perception improved within a week after she stopped carbamazepine. The second patient was aged around 12–13 years and had a depersonalisation disorder. He played the bass clarinet. He began carbamazepine 400 mg/day to treat impulsive violent behaviour, but 3–4 hours after he started the agent, he noticed a change in the pitch of his favourite music. During an examination 1 week later, he reported that carbamazepine caused him to hear sounds a semitone lower. He continued to take carbamazepine and did not report the pitch shift again. Two weeks later, tests revealed that his serum carbamazepine concentration on treatment day 7 had been 14.3 µg/ml, and his carbamazepine dosage was decreased to 300 mg/day. Author comment: ‘The mechanism of pitch perception shifts by carbamazepine is uncertain. It may range from subtle changes in complex brain functions to some changes in the mechanical properties of the organ of Corti. The fact that reported cases have predominantly experienced a downward shift of one semitone might also be of some significance.’ Kobayashi T, et al. Pitch perception shift: a rare side-effect of carbamazepine. Psychiatry and Clinical Neurosciences 55: 415-417, Aug 2001 - Japan 800877650 1 Reactions 6 Oct 2001 No. 872 0114-9954/10/0872-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 872 - 6 Oct 2001
Carbamazepine
Altered pitch perception in paediatric patients:2 case reports
Two paediatric patients experienced a pitch perception shiftduring treatment with carbamazepine.
The first patient was a 17-year-old girl with a dysthymicdisorder and schizoid personality traits. She had absolute pitchand played the piano. However, 2 days after she begancarbamazepine 400 mg/day, sulpiride and bromazepam tocontrol impulsive behaviour, she developed a significantchange in her perception of pitch. She reported that soundsseemed to have a lower pitch by a semitone. Her pitchperception improved within a week after she stoppedcarbamazepine.
The second patient was aged around 12–13 years and had adepersonalisation disorder. He played the bass clarinet. Hebegan carbamazepine 400 mg/day to treat impulsive violentbehaviour, but 3–4 hours after he started the agent, he noticeda change in the pitch of his favourite music. During anexamination 1 week later, he reported that carbamazepinecaused him to hear sounds a semitone lower. He continued totake carbamazepine and did not report the pitch shift again.Two weeks later, tests revealed that his serum carbamazepineconcentration on treatment day 7 had been 14.3 µg/ml, and hiscarbamazepine dosage was decreased to 300 mg/day.
Author comment: ‘The mechanism of pitch perceptionshifts by carbamazepine is uncertain. It may range from subtlechanges in complex brain functions to some changes in themechanical properties of the organ of Corti. The fact thatreported cases have predominantly experienced a downwardshift of one semitone might also be of some significance.’Kobayashi T, et al. Pitch perception shift: a rare side-effect of carbamazepine.Psychiatry and Clinical Neurosciences 55: 415-417, Aug 2001 - Japan 800877650
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Reactions 6 Oct 2001 No. 8720114-9954/10/0872-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
