Antineoplastics
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Reactions 452 - 22 May 1993 ★ Antineoplastics First report of post-treatment rheumatic disorders: 8 case reports Myalgias or arthralgias developed in 8 women, aged 40-53 years, within a few months of completing antineoplastic therapy for the treatment of breast cancer. All of the women received cyclophosphamide and fluorouracil along with 1 or more of the following drugs: methotrexate, doxorubicin, cisplatin, vincristine, dexamethasone and prednisone (Duration of antineoplastic therapy not documented). Stiffness was usually most noticeable after periods of inactivity and there was mild periarticular swelling in some cases. Bone and joint scans and serological tests for autoimmune markers were unremarkable Anti-inflammatories were administered but were ineffective. Symptoms resolved over 6-12 months without additional treatment in most cases, although 1 patient experienced a rapid, complete resolution of symptoms after receiving prednisone 7.5 mg/day. Author comment: These cases appear to describe a relatively similar, but previously unreported, clinical syndrome of arthralgias and myalgias. Symptoms developed within a few months of completing several months of cyclophosphamide/ fluorouracil-containing combination therapy and usually resolved spontaneously Loprinzi CL, et al. Postchemotherapy rheumatism. Journal of Clinical Oncology 11: 768-770, Apr 1993 - USA 800196325 1 Reactions 22 May 1993 No. 452 0114-9954/10/0452-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 452 - 22 May 1993
★Antineoplastics
First report of post-treatment rheumatic disorders:8 case reports
Myalgias or arthralgias developed in 8 women, aged 40-53years, within a few months of completing antineoplastictherapy for the treatment of breast cancer. All of the womenreceived cyclophosphamide and fluorouracil along with 1 ormore of the following drugs: methotrexate, doxorubicin,cisplatin, vincristine, dexamethasone and prednisone(Duration of antineoplastic therapy not documented). Stiffnesswas usually most noticeable after periods of inactivity andthere was mild periarticular swelling in some cases. Bone andjoint scans and serological tests for autoimmune markers wereunremarkable Anti-inflammatories were administered butwere ineffective. Symptoms resolved over 6-12 monthswithout additional treatment in most cases, although 1 patientexperienced a rapid, complete resolution of symptoms afterreceiving prednisone 7.5 mg/day.
Author comment: These cases appear to describe arelatively similar, but previously unreported, clinical syndromeof arthralgias and myalgias. Symptoms developed within a fewmonths of completing several months of cyclophosphamide/fluorouracil-containing combination therapy and usuallyresolved spontaneouslyLoprinzi CL, et al. Postchemotherapy rheumatism. Journal of Clinical Oncology11: 768-770, Apr 1993 - USA 800196325
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Reactions 22 May 1993 No. 4520114-9954/10/0452-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
