Antineoplastics
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Reactions 1429 - 24 Nov 2012 S Antineoplastics Gastric perforation: case report A 42-year-old woman experienced gastric perforation while receiving cyclophosphamide, doxorubicin, rituximab and vincristine [dosages and routes not stated] for gastric Burkitt-like lymphoma. She presented with acute abdominal pain and distension after the second course of chemotherapy [time to onset not stated]. Laparotomy showed perforation of the gastric corpus; she underwent primary closure to repair the perforation. Endoscopy showed an improvement and she subsequently received four more cycles of chemotherapy. There was no recurrence of disease at follow-up 3 years later. Author comment: "Our case presented with a large gastric ulcer and chemotherapy induced perforation developed. The perforation was thought to have occurred due to tumour cell necrosis in the anterior wall of the stomach after the second dose of chemotherapy." Ergun M, et al. A case of primary gastric Burkitt-like lymphoma with chemotherapy-induced perforation. Turkish Journal of Gastroenterology 23: 299-300, No. 3, Jun 2012. Available from: URL: http://dx.doi.org/10.4318/ tjg.2012.0373 - Turkey 803080152 1 Reactions 24 Nov 2012 No. 1429 0114-9954/10/1429-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1429 - 24 Nov 2012
SAntineoplastics
Gastric perforation: case reportA 42-year-old woman experienced gastric perforation
while receiving cyclophosphamide, doxorubicin, rituximaband vincristine [dosages and routes not stated] for gastricBurkitt-like lymphoma. She presented with acuteabdominal pain and distension after the second course ofchemotherapy [time to onset not stated]. Laparotomyshowed perforation of the gastric corpus; she underwentprimary closure to repair the perforation. Endoscopyshowed an improvement and she subsequently receivedfour more cycles of chemotherapy. There was norecurrence of disease at follow-up 3 years later.
Author comment: "Our case presented with a large gastriculcer and chemotherapy induced perforation developed. Theperforation was thought to have occurred due to tumour cellnecrosis in the anterior wall of the stomach after the seconddose of chemotherapy."Ergun M, et al. A case of primary gastric Burkitt-like lymphoma withchemotherapy-induced perforation. Turkish Journal of Gastroenterology 23:299-300, No. 3, Jun 2012. Available from: URL: http://dx.doi.org/10.4318/tjg.2012.0373 - Turkey 803080152
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Reactions 24 Nov 2012 No. 14290114-9954/10/1429-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
