Antineoplastics
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Reactions 1428 - 17 Nov 2012 S Antineoplastics Laryngeal nerve injury and hoarseness: case report A 34-year-old woman developed a laryngeal nerve injury complicated by hoarseness following chemotherapy for metastatic colon cancer [not all routes and frequencies stated]. The woman, who had adenocarcinoma of the sigmoid colon, was initially treated with FOLFOX-4 between May and August 2008. Due to disease progression and the development of liver metastases, she began receiving second-line chemotherapy with weekly cetuximab [Erbitux] and biweekly FOLFIRI in October 2009. Chemotherapy was delivered using an indwelling port-A catheter through the left subclavian vein. The regimen consisted of cetuximab 400 mg/m 2 loading dose, followed by a weekly maintenance dose of 250 mg/m 2 , irinotecan 180 mg/m 2 IV infusion for 90 min on day 1, fluorouracil 400 mg/m 2 bolus on day 1, folinic acid [leucovorin] 200 mg/m 2 and fluorouracil 2400 mg/m 2 46h infusion. In April 2010, after receiving 23 doses of cetuximab and 11 doses of FOLFIRI, she presented with hoarseness and mild retrosternal chest pain. Otolaryngology showed a paralysed left vocal cord, and a chest CT revealed extensive fluid infiltration into the superior and anterior mediastinum. Antegrade venography was performed, and contast medium retention was seen in the superior mediastinum. A laryngeal nerve injury complicated by hoarseness was confirmed. The hoarseness resolved spontaneously one week after chemotherapy. The port-A catheter was removed, and she made a complete recovery. Author comment: "Hoarseness could be a rare complication of port-A catheter malposition and extravasation of chemotherapeutic drugs. . . The clinical symptom of hoarseness occurred after chemotherapeutic agent infusion; therefore, chemotherapeutic agent-related transient recurrent laryngeal nerve injury complicated by hoarseness was confirmed." Wang JC, et al. Hoarseness: an unusual complication of port-A catheter perforation. Onkologie 35: 122-4, No. 3, Jan 2012 - Taiwan 803079771 1 Reactions 17 Nov 2012 No. 1428 0114-9954/10/1428-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1428 - 17 Nov 2012
SAntineoplastics
Laryngeal nerve injury and hoarseness: casereport
A 34-year-old woman developed a laryngeal nerve injurycomplicated by hoarseness following chemotherapy formetastatic colon cancer [not all routes and frequenciesstated].
The woman, who had adenocarcinoma of the sigmoidcolon, was initially treated with FOLFOX-4 between Mayand August 2008. Due to disease progression and thedevelopment of liver metastases, she began receivingsecond-line chemotherapy with weekly cetuximab[Erbitux] and biweekly FOLFIRI in October 2009.Chemotherapy was delivered using an indwelling port-Acatheter through the left subclavian vein. The regimenconsisted of cetuximab 400 mg/m2 loading dose, followedby a weekly maintenance dose of 250 mg/m2, irinotecan180 mg/m2 IV infusion for 90 min on day 1, fluorouracil400 mg/m2 bolus on day 1, folinic acid [leucovorin]200 mg/m2 and fluorouracil 2400 mg/m2 46h infusion. InApril 2010, after receiving 23 doses of cetuximab and11 doses of FOLFIRI, she presented with hoarseness andmild retrosternal chest pain. Otolaryngology showed aparalysed left vocal cord, and a chest CT revealed extensivefluid infiltration into the superior and anteriormediastinum. Antegrade venography was performed, andcontast medium retention was seen in the superiormediastinum. A laryngeal nerve injury complicated byhoarseness was confirmed. The hoarseness resolvedspontaneously one week after chemotherapy. The port-Acatheter was removed, and she made a complete recovery.
Author comment: "Hoarseness could be a rarecomplication of port-A catheter malposition and extravasationof chemotherapeutic drugs. . . The clinical symptom ofhoarseness occurred after chemotherapeutic agent infusion;therefore, chemotherapeutic agent-related transient recurrentlaryngeal nerve injury complicated by hoarseness wasconfirmed."Wang JC, et al. Hoarseness: an unusual complication of port-A catheterperforation. Onkologie 35: 122-4, No. 3, Jan 2012 - Taiwan 803079771
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Reactions 17 Nov 2012 No. 14280114-9954/10/1428-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
