Antineoplastics
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Reactions 1311 - 24 Jul 2010 Antineoplastics Various toxicities in elderly patients: 3 case reports Three women aged 86, 88 and 93 years with diffuse large B-cell lymphoma started receiving R-CHOP chemotherapy with IV rituximab 375 mg/m 2 on day 1, oral prednisolone on days 1–5, and IV cyclophosphamide 750mg, IV mitoxantrone 8mg and IV vincristine 1mg on day 2 [cycle duration not stated]. One woman developed grade III leucopenia after cycle 2; she subsequently received prophylactic granulocyte colony stimulating factor. Grade II anaemia developed after cycle 6 in another patient; she received darbepoetin during the next two cycles. Mild nausea and vomiting occurred in two patients, one woman developed an upper urinary tract infection requiring antibiotic therapy, and another woman received a quinolone for an episode of bronchitis. Two women received a total of six cycles, and one woman received eight cycles; all achieved complete remission [not all outcomes stated]. Jonak C, et al. Rituximab plus dose-reduced cyclophosphamide, mitoxantrone, vincristine, and prednisolone are effective in elderly patients with diffuse large B- Cell lymphoma of the thyroid. Thyroid 20: 425-427, No. 4, Apr 2010. Available from: URL: http://dx.doi.org/10.1089/thy.2009.0440 - Austria 803027455 1 Reactions 24 Jul 2010 No. 1311 0114-9954/10/1311-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1311 - 24 Jul 2010
Antineoplastics
Various toxicities in elderly patients: 3 casereports
Three women aged 86, 88 and 93 years with diffuse largeB-cell lymphoma started receiving R-CHOP chemotherapywith IV rituximab 375 mg/m2 on day 1, oral prednisoloneon days 1–5, and IV cyclophosphamide 750mg, IVmitoxantrone 8mg and IV vincristine 1mg on day 2 [cycleduration not stated]. One woman developed grade IIIleucopenia after cycle 2; she subsequently receivedprophylactic granulocyte colony stimulating factor. Grade IIanaemia developed after cycle 6 in another patient; shereceived darbepoetin during the next two cycles. Mildnausea and vomiting occurred in two patients, one womandeveloped an upper urinary tract infection requiringantibiotic therapy, and another woman received aquinolone for an episode of bronchitis. Two womenreceived a total of six cycles, and one woman received eightcycles; all achieved complete remission [not all outcomesstated].Jonak C, et al. Rituximab plus dose-reduced cyclophosphamide, mitoxantrone,vincristine, and prednisolone are effective in elderly patients with diffuse large B-Cell lymphoma of the thyroid. Thyroid 20: 425-427, No. 4, Apr 2010. Availablefrom: URL: http://dx.doi.org/10.1089/thy.2009.0440 - Austria 803027455
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Reactions 24 Jul 2010 No. 13110114-9954/10/1311-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
