Antineoplastics
1
Reactions 1282 - 12 Dec 2009 S Antineoplastics Sepsis: 2 case reports Two patients with HIV infection experienced sepsis during treatment with antineoplastics for Hodgkin’s lymphoma. A 43-year-old man, who had a history of HIV infection and diffuse large B cell lymphoma treated with CHOP, was diagnosed with classical Hodgkin’s lymphoma. He started receiving chlorambucil, prednisone, procarbazine and vinblastine [dosages not stated]. Twelve days after his first cycle was started, he developed sepsis due to Streptococcus mitis, which led to respiratory insufficiency and profound hypotension. He was admitted to an ICU where he stayed for 2 months and received prolonged treatment with corticosteroids, antibacterials and vasopressors. He was intubated and underwent renal dialysis. During this time, his antiretrovirals were held. He recovered and was discharged to a rehabilitation unit, where he stayed for several months. Five months after chemotherapy, imaging revealed a complete response. After 4 years, he was still in remission despite not receiving further chemotherapy. A 55-year-old man, who had been diagnosed with HIV infection 9 years ago, was diagnosed with classical Hodgkin’s lymphoma. He received his first course of chemotherapy with bleomycin, doxorubicin, dacarbazine and vinblastine [dosages not stated]. Eleven days later, he presented with sepsis and respiratory distress. He received aggressive supportive therapy and survived. However, he remained ventilator dependent. Subsequently, he was transferred to a long-term care unit and weaned off ventilatory support; he did not receive any further chemotherapy. Nearly 5 months after admission, he was discharged home. On discharge, a CT scan did not reveal any evidence of disease. Four years later, he was in complete remission. Martin P, et al. Durable complete remissions in HIV-associated hodgkin lymphoma after treatment with only one cycle of chemotherapy complicated by sepsis. Clinical Lymphoma & Myeloma 9: 247-249, No. 3, Jun 2009 - USA 801154819 1 Reactions 12 Dec 2009 No. 1282 0114-9954/10/1282-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1282 - 12 Dec 2009
SAntineoplastics
Sepsis: 2 case reportsTwo patients with HIV infection experienced sepsis
during treatment with antineoplastics for Hodgkin’slymphoma.
A 43-year-old man, who had a history of HIV infectionand diffuse large B cell lymphoma treated with CHOP, wasdiagnosed with classical Hodgkin’s lymphoma. He startedreceiving chlorambucil, prednisone, procarbazine andvinblastine [dosages not stated]. Twelve days after his firstcycle was started, he developed sepsis due toStreptococcus mitis, which led to respiratory insufficiencyand profound hypotension. He was admitted to an ICUwhere he stayed for 2 months and received prolongedtreatment with corticosteroids, antibacterials andvasopressors. He was intubated and underwent renaldialysis. During this time, his antiretrovirals were held. Herecovered and was discharged to a rehabilitation unit,where he stayed for several months. Five months afterchemotherapy, imaging revealed a complete response.After 4 years, he was still in remission despite not receivingfurther chemotherapy.
A 55-year-old man, who had been diagnosed with HIVinfection 9 years ago, was diagnosed with classicalHodgkin’s lymphoma. He received his first course ofchemotherapy with bleomycin, doxorubicin, dacarbazineand vinblastine [dosages not stated]. Eleven days later, hepresented with sepsis and respiratory distress. He receivedaggressive supportive therapy and survived. However, heremained ventilator dependent. Subsequently, he wastransferred to a long-term care unit and weaned offventilatory support; he did not receive any furtherchemotherapy. Nearly 5 months after admission, he wasdischarged home. On discharge, a CT scan did not revealany evidence of disease. Four years later, he was incomplete remission.Martin P, et al. Durable complete remissions in HIV-associated hodgkin lymphomaafter treatment with only one cycle of chemotherapy complicated by sepsis.Clinical Lymphoma & Myeloma 9: 247-249, No. 3, Jun 2009 - USA 801154819
1
Reactions 12 Dec 2009 No. 12820114-9954/10/1282-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
