Antineoplastics
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Reactions 1468, p8 - 7 Sep 2013 S Antineoplastics Peripheral neuropathy: case report A 41-year-old man developed peripheral neuropathy during chemotherapy with cisplatin, etoposide, paclitaxel and ifosfamide for recurrence of a nonseminomatous germ cell tumour (NSGCT) of the testis; his neuropathy worsened after further chemotherapy with irinotecan and nedaplatin [dosages and routes not stated]. The man had been diagnosed with NSGCT at age 25 years and, at that time, underwent right orchiectomy and chemotherapy with cisplatin, vinblastine, cyclophosphamide, dactinomycin and bleomycin. In September 2007, at the age of 41 years, he was diagnosed with late recurrence of NSGCT, invading the 11th and 12th thoracic vertebrae and surrounding thoracic aorta, and underwent salvage chemotherapy. After one cycle of etoposide and cisplatin and two cycles of cisplatin, paclitaxel and ifosfamide, he developed severe chemotherapy-induced peripheral neuropathy (Grade 2). Following two additional cycles of chemotherapy with alternative regimens containing nedaplatin and irinotecan, his neuropathy worsened to Grade 3 and chemotherapy could not be continued [patient outcome not stated]. He received intensity-modulated radiation therapy for his NSGCT and subsequently achieved complete clinical remission. Author comment: "[C]hemotherapy could not be continued due to its neurotoxicity". Kita Y, et al. Late recurrence of nonseminomatous germ cell tumor successfully treated with intensity-modulated radiation therapy. Japanese Journal of Clinical Oncology 43: 835-837, No. 8, Aug 2013. Available from: URL: http:// dx.doi.org/10.1093/jjco/hyt090 - Japan 803092327 1 Reactions 7 Sep 2013 No. 1468 0114-9954/13/1468-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1468, p8 - 7 Sep 2013
SAntineoplastics
Peripheral neuropathy: case reportA 41-year-old man developed peripheral neuropathy during
chemotherapy with cisplatin, etoposide, paclitaxel andifosfamide for recurrence of a nonseminomatous germ celltumour (NSGCT) of the testis; his neuropathy worsened afterfurther chemotherapy with irinotecan and nedaplatin [dosagesand routes not stated].
The man had been diagnosed with NSGCT at age 25 yearsand, at that time, underwent right orchiectomy andchemotherapy with cisplatin, vinblastine, cyclophosphamide,dactinomycin and bleomycin. In September 2007, at the age of41 years, he was diagnosed with late recurrence of NSGCT,invading the 11th and 12th thoracic vertebrae and surroundingthoracic aorta, and underwent salvage chemotherapy. Afterone cycle of etoposide and cisplatin and two cycles ofcisplatin, paclitaxel and ifosfamide, he developed severechemotherapy-induced peripheral neuropathy (Grade 2).Following two additional cycles of chemotherapy withalternative regimens containing nedaplatin and irinotecan, hisneuropathy worsened to Grade 3 and chemotherapy could notbe continued [patient outcome not stated]. He receivedintensity-modulated radiation therapy for his NSGCT andsubsequently achieved complete clinical remission.
Author comment: "[C]hemotherapy could not becontinued due to its neurotoxicity".Kita Y, et al. Late recurrence of nonseminomatous germ cell tumor successfullytreated with intensity-modulated radiation therapy. Japanese Journal of ClinicalOncology 43: 835-837, No. 8, Aug 2013. Available from: URL: http://dx.doi.org/10.1093/jjco/hyt090 - Japan 803092327
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Reactions 7 Sep 2013 No. 14680114-9954/13/1468-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
