Reactions 397 - 18 Apr 1992

Antineoplastics

Adverse effects: clinical studyFatigue syndrome lasting 4-8 weeks, chemical and

ischaemic hepatitis, severe thrombocytopenia and icterusoccurred following whole liver chemoembolisation in 7evaluable patients. The patients had unresectable colorectalcancer, metastatic to the liver, and good performance statusThey received ’Angiostat’, a vaso-occlusive collagen,mitomycin, doxorubicin +/- cisplatin.

The authors suggested limiting the use ofchemoembolisation in metastatic colorectal cancer to patientswhose disease continues to progress after systemic or hepaticarterial antineoplastic therapy. They also suggestedperforming staged unilobar chemoembolisations at 4- to6-week intervals rather than whole liver chemoembolisation inorder to reduce toxicityBorner M, et al. Considerable side effects of chemoembolization for colorectalcarcinoma metastatic to the liver cancer. Annals of Oncology 3: 113-115, Feb 1992- Switzerland 800127310

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Reactions 18 Apr 1992 No. 3970114-9954/10/0397-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved