Oxcarbazepine
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Reactions 1044 - 26 Mar 2005 ★ Oxcarbazepine First report of immunoglobulin deficiency: case report A 49-year-old woman developed immunoglobulin deficiency during treatment with oxcarbazepine [dosage and duration of treatment not stated] for chronic pain. During evaluation for chronic bacterial vaginitis, the woman was found to have low serum immunoglobulin levels, with an IgG level of 576 mg/dL, an IgA level of < 11 mg/dL and an IgM level of < 4 mg/dL. She also had a low B cell count of 18 cells/mm 3 (normal 75–375). Oxcarbazepine was discontinued, but the woman’s immunoglobulin levels remained low over the next 2 months. Her IgG and IgM levels normalised after 8 months, as did her B cell count. However, IgA deficiency persisted, with IgA levels of < 7 and < 15 mg/dL at 8 and 12 months, respectively. Author comment: "It is unclear if persistent IgA deficiency was a pre-existing condition, possibly predisposing her to this adverse reaction to oxcarbazepine, or induced by the oxcarbazepine." Knight AK, et al. Oxcarbazepine induced immunoglobulin deficiency. Annals of Allergy, Asthma and Immunology 94: 157, No. 1, Jan 2005 [abstract] - USA 801003093 » Editorial comment: A search of AdisBase, Medline and the WHO Adverse Drug Reactions database did not reveal any previous case reports of immunoglobulin deficiency associated with oxcarbazepine. 1 Reactions 26 Mar 2005 No. 1044 0114-9954/10/1044-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Oxcarbazepine
Reactions 1044 - 26 Mar 2005
★Oxcarbazepine
First report of immunoglobulin deficiency: casereport
A 49-year-old woman developed immunoglobulindeficiency during treatment with oxcarbazepine [dosage andduration of treatment not stated] for chronic pain.
During evaluation for chronic bacterial vaginitis, the womanwas found to have low serum immunoglobulin levels, with anIgG level of 576 mg/dL, an IgA level of < 11 mg/dL and an IgMlevel of < 4 mg/dL. She also had a low B cell count of18 cells/mm3 (normal 75–375).
Oxcarbazepine was discontinued, but the woman’simmunoglobulin levels remained low over the next 2 months.Her IgG and IgM levels normalised after 8 months, as did herB cell count. However, IgA deficiency persisted, with IgA levelsof < 7 and < 15 mg/dL at 8 and 12 months, respectively.
Author comment: "It is unclear if persistent IgA deficiencywas a pre-existing condition, possibly predisposing her to thisadverse reaction to oxcarbazepine, or induced by theoxcarbazepine."Knight AK, et al. Oxcarbazepine induced immunoglobulin deficiency. Annals ofAllergy, Asthma and Immunology 94: 157, No. 1, Jan 2005 [abstract] -USA 801003093
» Editorial comment: A search of AdisBase, Medline and theWHO Adverse Drug Reactions database did not reveal anyprevious case reports of immunoglobulin deficiency associatedwith oxcarbazepine.
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Reactions 26 Mar 2005 No. 10440114-9954/10/1044-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
