Oxcarbazepine
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Reactions 1386 - 28 Jan 2012 S Oxcarbazepine Interstitial pneumonitis: case report A patient [sex not stated] developed interstitial pneumonitis during treatment with oxcarbazepine for pain. The patient [age stated to be 49 years old; age at reaction onset not clearly stated], who had been diagnosed with syringomyelia and Arnold Chiari malformation from the age of 19 years, was followed in an outpatient clinic and received oxcarbazepine [route and dosage not stated], oxycodone, and amitriptyline. In April 2009, the patient developed probable cryptogenic organising pneumonia with respiratory distress [duration of treatment to reaction onset not stated]. The patient required orotracheal intubation for 13 days and showed a good response to corticosteroids. In February 2010, the patient was again diagnosed with bilateral interstitial pneumonitis and received corticosteroids with a good response. Oxcarbazepine and oxycodone were withdrawn and replaced with fentanyl and gabapentin. Revisions to the patient’s treatment were made and oxycodone was reintroduced. There were no new occurrences of lung injury. Antonio P. Pulmonar toxicity and treatment of neuropathic pain. European Journal of Pain Supplements 5: 238, No. 1, Sep 2011 [abstract] - Spain 803066246 1 Reactions 28 Jan 2012 No. 1386 0114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Oxcarbazepine
Reactions 1386 - 28 Jan 2012
SOxcarbazepine
Interstitial pneumonitis: case reportA patient [sex not stated] developed interstitial
pneumonitis during treatment with oxcarbazepine for pain.The patient [age stated to be 49 years old; age at reaction
onset not clearly stated], who had been diagnosed withsyringomyelia and Arnold Chiari malformation from the ageof 19 years, was followed in an outpatient clinic andreceived oxcarbazepine [route and dosage not stated],oxycodone, and amitriptyline. In April 2009, the patientdeveloped probable cryptogenic organising pneumoniawith respiratory distress [duration of treatment to reactiononset not stated].
The patient required orotracheal intubation for 13 daysand showed a good response to corticosteroids. InFebruary 2010, the patient was again diagnosed withbilateral interstitial pneumonitis and receivedcorticosteroids with a good response. Oxcarbazepine andoxycodone were withdrawn and replaced with fentanyl andgabapentin. Revisions to the patient’s treatment were madeand oxycodone was reintroduced. There were no newoccurrences of lung injury.Antonio P. Pulmonar toxicity and treatment of neuropathic pain. European Journalof Pain Supplements 5: 238, No. 1, Sep 2011 [abstract] - Spain 803066246
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Reactions 28 Jan 2012 No. 13860114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
