Oxcarbazepine
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Reactions 1434 - 12 Jan 2013 ★ Oxcarbazepine First report of retrograde ejaculation: case report A 35-year-old man experienced retrograde ejaculation while receiving oxcarbazepine to treat post-traumatic epilepsy. The man starting having weekly seizures about 1 year after a brain injury and was initiated on oxcarbazepine, which was gradually titrated up to 1800 mg/day [route not stated]. While on titration, he reported difficulty in achieving ejaculation, and presented with complete anejaculation a few days after reaching the maximal dosage. His sexual history was unremarkable, and his sexual drive and erections were unaltered. He noted that his postorgasm urine was foamy, and urinalysis revealed the presence of semen. Iatrogenic retrograde ejaculation was suspected. The man’s oxcarbazepine therapy was gradually discontinued, and topiramate was initiated without seizures or sexual side effects. One week after oxcarbazepine was withdrawn, he presented with anterograde ejaculation, and no semen was found in his urine at 30 days’ follow-up. Author comment: "We, herein, describe a patient with post-traumatic epilepsy who presented with [retrograde ejaculation] caused by [oxcarbazepine] consumption". Calabro RS, et al. Oxcarbazepine-related retrograde ejaculation. Epilepsy and Behavior 25: 174-175, No. 2, Oct 2012. Available from: URL: http:// dx.doi.org/10.1016/j.yebeh.2012.08.025 - Italy 803081979 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of retrograde ejaculation associated with oxcarbazepine. The WHO ADR database did not contain any reports of retrograde ejaculation associated with oxcarbazepine. 1 Reactions 12 Jan 2013 No. 1434 0114-9954/10/1434-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1434 - 12 Jan 2013
★Oxcarbazepine
First report of retrograde ejaculation: case reportA 35-year-old man experienced retrograde ejaculation while
receiving oxcarbazepine to treat post-traumatic epilepsy.The man starting having weekly seizures about 1 year after a
brain injury and was initiated on oxcarbazepine, which wasgradually titrated up to 1800 mg/day [route not stated]. Whileon titration, he reported difficulty in achieving ejaculation, andpresented with complete anejaculation a few days afterreaching the maximal dosage. His sexual history wasunremarkable, and his sexual drive and erections wereunaltered. He noted that his postorgasm urine was foamy, andurinalysis revealed the presence of semen. Iatrogenicretrograde ejaculation was suspected.
The man’s oxcarbazepine therapy was graduallydiscontinued, and topiramate was initiated without seizures orsexual side effects. One week after oxcarbazepine waswithdrawn, he presented with anterograde ejaculation, and nosemen was found in his urine at 30 days’ follow-up.
Author comment: "We, herein, describe a patient withpost-traumatic epilepsy who presented with [retrogradeejaculation] caused by [oxcarbazepine] consumption".Calabro RS, et al. Oxcarbazepine-related retrograde ejaculation. Epilepsy andBehavior 25: 174-175, No. 2, Oct 2012. Available from: URL: http://dx.doi.org/10.1016/j.yebeh.2012.08.025 - Italy 803081979
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of retrogradeejaculation associated with oxcarbazepine. The WHO ADRdatabase did not contain any reports of retrograde ejaculationassociated with oxcarbazepine.
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Reactions 12 Jan 2013 No. 14340114-9954/10/1434-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
