Oxcarbazepine
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Reactions 1479, p25-26 - 23 Nov 2013 S Oxcarbazepine Complete atrioventricular block in an elderly patient: case report A 67-year-old woman developed complete atrioventricular (AV) block while receiving oxcarbazepine for partial seizures. The woman presented to an emergency service with severe headaches and fatigue. Her symptoms had been intermittent since she started receiving oxcarbazepine 300mg twice daily 2 years earlier [route and time to reaction onset not stated]. On admission, cardiac examination found bradycardia; following an ECG, she was transferred to a cardiology clinic with a diagnosis of complete atrioventricular block. The woman received a temporary pacemaker. ECG found grade 1 diastolic dysfunction, and oxcarbazepine was withdrawn; she started receiving levetiracetam. Three days later, she developed 2:1 AV block followed by normal sinus rhythm. No arrhythmia was detected on 24-hour Holter monitoring. The pacemaker was removed, and she was discharged. No bradycardia or conduction disorders were found during follow-up. Author comment: "[A]nother reason of complete AV block might be the effect of [oxcarbazepine] on potassium channels." Karabag T, et al. A rare complication during oxcarbazepine use, complete atrioventricular block: Case report. Turkiye Klinikleri Cardiovascular Sciences 25: 26-28, No. 1, 10 Oct 2013. Available from: URL: http:// www.turkiyeklinikleri.com/article/en-a-rare-complication-during-oxcarbazepine- use-complete-atrioventricular-block-case-report-66107.html - Turkey 803095847 1 Reactions 23 Nov 2013 No. 1479 0114-9954/13/1479-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1479, p25-26 - 23 Nov 2013
SOxcarbazepine
Complete atrioventricular block in an elderlypatient: case report
A 67-year-old woman developed complete atrioventricular(AV) block while receiving oxcarbazepine for partial seizures.
The woman presented to an emergency service with severeheadaches and fatigue. Her symptoms had been intermittentsince she started receiving oxcarbazepine 300mg twice daily2 years earlier [route and time to reaction onset not stated]. Onadmission, cardiac examination found bradycardia; followingan ECG, she was transferred to a cardiology clinic with adiagnosis of complete atrioventricular block.
The woman received a temporary pacemaker. ECG foundgrade 1 diastolic dysfunction, and oxcarbazepine waswithdrawn; she started receiving levetiracetam. Three dayslater, she developed 2:1 AV block followed by normal sinusrhythm. No arrhythmia was detected on 24-hour Holtermonitoring. The pacemaker was removed, and she wasdischarged. No bradycardia or conduction disorders werefound during follow-up.
Author comment: "[A]nother reason of complete AV blockmight be the effect of [oxcarbazepine] on potassiumchannels."Karabag T, et al. A rare complication during oxcarbazepine use, completeatrioventricular block: Case report. Turkiye Klinikleri Cardiovascular Sciences 25:26-28, No. 1, 10 Oct 2013. Available from: URL: http://www.turkiyeklinikleri.com/article/en-a-rare-complication-during-oxcarbazepine-use-complete-atrioventricular-block-case-report-66107.html - Turkey 803095847
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Reactions 23 Nov 2013 No. 14790114-9954/13/1479-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
