Lorazepam
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Reactions 1408 - 30 Jun 2012 ★ Lorazepam First report of paresis of accommodation: case report A 23-year-old man developed paresis of accommodation in both eyes during treatment with lorazepam [Ativan] for depression. The man received lorazepam 1.5 mg/day [route not stated] alongside fluoxetine therapy. He developed near- sight disturbance in both eyes 5 days after starting lorazepam but did not present until 2 weeks after treatment initiation. Visual examination revealed visual acuity of 1.0 in both eyes but disturbed near point of accommodation (NPA); 16cm OD and 19cm OS. Sluggish pupillary reflex was also evident in both eyes. The man’s near-sight disturbance was relieved by near glasses correction. Lorazepam was discontinued 7 days after presentation and replaced with diazepam. NPA 15 days after lorazepam cessation had improved to 14cm OD and 12cm OS. Recovery of NPA to 6cm in both eyes was evident 2 months after drug discontinuation. Author comment: "In the present case, near-sight disturbance with prolonged NPA was noted and the symptom was relieved after cessation of lorazepam. Thus, lorazepam can induce accommodation insufficiency." Jung JJ, et al. A case of lorazepam (Ativan)-induced accommodation paresis. Eye 26: 614, No. 4, Apr 2012. Available from: URL: http://dx.doi.org/10.1038/ eye.2011.346 - South Korea 803072598 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of paresis of accommodation associated with lorazepam. The WHO ADR database contained 12 reports of accommodation disorder associated with lorazepam. 1 Reactions 30 Jun 2012 No. 1408 0114-9954/10/1408-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Lorazepam
Reactions 1408 - 30 Jun 2012
★Lorazepam
First report of paresis of accommodation: casereport
A 23-year-old man developed paresis of accommodationin both eyes during treatment with lorazepam [Ativan] fordepression.
The man received lorazepam 1.5 mg/day [route notstated] alongside fluoxetine therapy. He developed near-sight disturbance in both eyes 5 days after startinglorazepam but did not present until 2 weeks after treatmentinitiation. Visual examination revealed visual acuity of 1.0 inboth eyes but disturbed near point of accommodation(NPA); 16cm OD and 19cm OS. Sluggish pupillary reflexwas also evident in both eyes.
The man’s near-sight disturbance was relieved by nearglasses correction. Lorazepam was discontinued 7 daysafter presentation and replaced with diazepam. NPA15 days after lorazepam cessation had improved to 14cmOD and 12cm OS. Recovery of NPA to 6cm in both eyeswas evident 2 months after drug discontinuation.
Author comment: "In the present case, near-sightdisturbance with prolonged NPA was noted and the symptomwas relieved after cessation of lorazepam. Thus, lorazepamcan induce accommodation insufficiency."Jung JJ, et al. A case of lorazepam (Ativan)-induced accommodation paresis. Eye26: 614, No. 4, Apr 2012. Available from: URL: http://dx.doi.org/10.1038/eye.2011.346 - South Korea 803072598
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of paresisof accommodation associated with lorazepam. The WHOADR database contained 12 reports of accommodationdisorder associated with lorazepam.
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Reactions 30 Jun 2012 No. 14080114-9954/10/1408-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
