Carbamazepine/escitalopram/indapamide
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Reactions 1347 - 16 Apr 2011 S Carbamazepine/escitalopram/ indapamide Hyponatraemia in elderly patients: 2 case reports Two women aged 71 and 91 years, respectively, developed hyponatraemia while receiving carbamazepine and indapamide, and escitalopram [dosages, routes and therapeutic indications not stated]. Hyponatraemia was detected in the older woman following admission to the emergency department for leg pain. On starting treatment with escitalopram 1 month earlier, her serum sodium level was 139 mmol/L; on presentation her sodium level had fallen to 124 mmol/L. Escitalopram was suspected and discontinued, and she was managed with fluid restriction and sodium replacement [outcome not stated]. The second woman experienced mental deterioration while receiving carbamazepine and indapamide [time to reaction onset not stated]. Testing revealed severe hyponatraemia (serum sodium 114 mmol/L). Her symptoms resolved after both drugs were discontinued. See also this issue p4; 803052725 Therapeutic Goods Administration. Drug-induced hyponatraemia Medicines Safety Update 2: No. 2, Apr 2011 - Australia 803052814 1 Reactions 16 Apr 2011 No. 1347 0114-9954/10/1347-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine/escitalopram/indapamide
Reactions 1347 - 16 Apr 2011
SCarbamazepine/escitalopram/indapamide
Hyponatraemia in elderly patients: 2 case reportsTwo women aged 71 and 91 years, respectively,
developed hyponatraemia while receiving carbamazepineand indapamide, and escitalopram [dosages, routes andtherapeutic indications not stated].
Hyponatraemia was detected in the older womanfollowing admission to the emergency department for legpain. On starting treatment with escitalopram 1 monthearlier, her serum sodium level was 139 mmol/L; onpresentation her sodium level had fallen to 124 mmol/L.Escitalopram was suspected and discontinued, and she wasmanaged with fluid restriction and sodium replacement[outcome not stated].
The second woman experienced mental deteriorationwhile receiving carbamazepine and indapamide [time toreaction onset not stated]. Testing revealed severehyponatraemia (serum sodium 114 mmol/L). Hersymptoms resolved after both drugs were discontinued.
See also this issue p4; 803052725
Therapeutic Goods Administration. Drug-induced hyponatraemia Medicines SafetyUpdate 2: No. 2, Apr 2011 - Australia 803052814
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Reactions 16 Apr 2011 No. 13470114-9954/10/1347-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
