Carbamazepine overdose
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Reactions 491 - 5 Mar 1994 S Carbamazepine overdose Dystonia: case report After ingesting 8 tablets of carbamazepine 200mg, which belonged to her grandmother, a 13-year-old girl developed dystonia. The girl was admitted 3 hours after developing altered sensorium and unnatural posturing of her trunk and extremities. She had frequent abnormal movements, was comatosed and responded only to painful stimulus. Gastric lavage was performed and supportive care given. The following day, a down-beat nystagmus became detectable, and by day 3 she had regained consciousness. Author comment ‘Dystonia is a distinctly uncommon manifestation associated with carbamazepine toxicity and has been reported only infrequently . . . The temporal relationship of ingestion of 1600mg of carbamazepine to the occurrence of dystonia and nystagmus, and the disappearance of these symptoms over the next 2 days establishes a causal relationship.’ Soman P, et al. Dystonia - a rare manifestation of carbamazepine toxicity. Postgraduate Medical Journal 70: 54-55, Jan 1994 - India 800252144 1 Reactions 5 Mar 1994 No. 491 0114-9954/10/0491-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine overdose
Reactions 491 - 5 Mar 1994
SCarbamazepine overdose
Dystonia: case reportAfter ingesting 8 tablets of carbamazepine 200mg, which
belonged to her grandmother, a 13-year-old girl developeddystonia.
The girl was admitted 3 hours after developing alteredsensorium and unnatural posturing of her trunk andextremities. She had frequent abnormal movements, wascomatosed and responded only to painful stimulus. Gastriclavage was performed and supportive care given.
The following day, a down-beat nystagmus becamedetectable, and by day 3 she had regained consciousness.
Author comment ‘Dystonia is a distinctly uncommonmanifestation associated with carbamazepine toxicity and hasbeen reported only infrequently . . . The temporal relationshipof ingestion of 1600mg of carbamazepine to the occurrence ofdystonia and nystagmus, and the disappearance of thesesymptoms over the next 2 days establishes a causalrelationship.’Soman P, et al. Dystonia - a rare manifestation of carbamazepine toxicity.Postgraduate Medical Journal 70: 54-55, Jan 1994 - India 800252144
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Reactions 5 Mar 1994 No. 4910114-9954/10/0491-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
