Carbamazepine overdose
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Reactions 426 - 7 Nov 1992 Carbamazepine overdose Adverse effects related to serum concentrations in children: clinical study Patients with serum carbamazepine levels of approximately 100 micromol/L should be monitored closely and treated with gastric lavage and/or activated charcoal, whereas patients with levels of approximately 150 micromol/l may require intensive life support. This was recommended by Mr J Tibballs from the Royal Children’s Hospital, Melbourne, Australia, based on results of a study of 82 children (1-17 years of age) admitted with carbamazepine poisoning. Ten children in a deep coma had a mean peak serum carbamazepine level of 213 micromol/L. Six of these patients experienced seizures, 8 required mechanical ventilation and 4 required inotropic- vasopressor support; 2 patients died of left ventricular failure and aspiration pneumonitis, respectively. 27 patients in a moderate coma had a mean serum carbamazepine level of 112 micromol/L Tachycardia was common in these patients and 2 experienced seizures Treatment in this group consisted of intensive nursing, gastric lavage and activated charcoal. In 45 children with a mean serum carbamazepine level of 73 micromol/L, symptoms experienced included drowsiness, ataxia, nystagmus, dystonia, vomiting and occasionally hallucinations. Nine of these patients were treated with emesis or gastric lavage and activated charcoal Tibballs J. Acute toxic reaction to carbamazepine: clinical effects and serum concentrations. Journal of Pediatrics 121: 295-299, Aug 1992 - Australia 800163306 1 Reactions 7 Nov 1992 No. 426 0114-9954/10/0426-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine overdose
Reactions 426 - 7 Nov 1992
Carbamazepine overdose
Adverse effects related to serum concentrations inchildren: clinical study
Patients with serum carbamazepine levels of approximately100 micromol/L should be monitored closely and treated withgastric lavage and/or activated charcoal, whereas patients withlevels of approximately 150 micromol/l may require intensivelife support. This was recommended by Mr J Tibballs from theRoyal Children’s Hospital, Melbourne, Australia, based onresults of a study of 82 children (1-17 years of age) admittedwith carbamazepine poisoning. Ten children in a deep comahad a mean peak serum carbamazepine level of 213micromol/L. Six of these patients experienced seizures, 8required mechanical ventilation and 4 required inotropic-vasopressor support; 2 patients died of left ventricular failureand aspiration pneumonitis, respectively. 27 patients in amoderate coma had a mean serum carbamazepine level of 112micromol/L Tachycardia was common in these patients and 2experienced seizures Treatment in this group consisted ofintensive nursing, gastric lavage and activated charcoal. In 45children with a mean serum carbamazepine level of 73micromol/L, symptoms experienced included drowsiness,ataxia, nystagmus, dystonia, vomiting and occasionallyhallucinations. Nine of these patients were treated with emesisor gastric lavage and activated charcoalTibballs J. Acute toxic reaction to carbamazepine: clinical effects and serumconcentrations. Journal of Pediatrics 121: 295-299, Aug 1992 -Australia 800163306
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Reactions 7 Nov 1992 No. 4260114-9954/10/0426-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
