Carbamazepine
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Reactions 530 - 3 Dec 1994 S Carbamazepine Stevens Johnson syndrome: case report A 43-year-old woman developed Stevens Johnson syndrome 2 weeks after she started treatment with carbamazepine 100mg bid for severe neuralgia. The woman was admitted with fever and progressive generalised erythematous macular and bullous skin lesions. The rash had first appeared on her extremities but then spread to her trunk, neck, face, palms, oral mucosa and conjunctiva. Corneal erosion was evident in her right eye and she had haemorrhagic crusting in her nasal cavity. The patient was given IV fluids and high-dose corticosteroids. She was discharged 2 weeks later, and, at 6 months’ follow-up, remained asymptomatic. Author comment: Although relatively few reports of carbamazepine-induced Stevens-Johnson syndrome have been published, patients should be warned to report any skin rash. Hur T, et al. Stevens-Johnson syndrome due to carbamazepine hypersensitivity. Drug Investigation 8: 316-319, Nov 1994 - Taiwan 800315386 1 Reactions 3 Dec 1994 No. 530 0114-9954/10/0530-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 530 - 3 Dec 1994
SCarbamazepine
Stevens Johnson syndrome: case reportA 43-year-old woman developed Stevens Johnson syndrome
2 weeks after she started treatment with carbamazepine100mg bid for severe neuralgia.
The woman was admitted with fever and progressivegeneralised erythematous macular and bullous skin lesions.The rash had first appeared on her extremities but then spreadto her trunk, neck, face, palms, oral mucosa and conjunctiva.Corneal erosion was evident in her right eye and she hadhaemorrhagic crusting in her nasal cavity.
The patient was given IV fluids and high-dosecorticosteroids. She was discharged 2 weeks later, and, at 6months’ follow-up, remained asymptomatic.
Author comment: Although relatively few reports ofcarbamazepine-induced Stevens-Johnson syndrome have beenpublished, patients should be warned to report any skin rash.Hur T, et al. Stevens-Johnson syndrome due to carbamazepine hypersensitivity.Drug Investigation 8: 316-319, Nov 1994 - Taiwan 800315386
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Reactions 3 Dec 1994 No. 5300114-9954/10/0530-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
