Carbamazepine
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Reactions 508 - 2 Jul 1994 S Carbamazepine Erythema multiforme and toxic epidermal necrolysis: case report Erythema multiforme and toxic epidermal necrolysis (TEN) developed in a 19-year-old woman 14 days after she started carbamazepine 600 mg/day for epilepsy. Carbamazepine was discontinued and oral prednisolone was started. However, TEN progressed to involve 60% of the body surface, thus plasmapheresis was started. The activity of toxic epidermal necrolysis was reduced during plasmapheresis but increased again after it was stopped. Gammaglobulin was then given for 5 days; during this time extensive re- epithelialisation occurred. Authors comment: Investigations of this case suggest that the pathogenesis of erythema multiforme and toxic epidermal necrolysis may involve a combination of immune hypersensitivity reactions and reactions mediated by toxic intermediates generated by impaired or altered drug metabolism. Friedmann PS, et al. Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine. Archives of Dermatology 130: 598-604, May 1994 - England 800270961 1 Reactions 2 Jul 1994 No. 508 0114-9954/10/0508-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 508 - 2 Jul 1994
SCarbamazepine
Erythema multiforme and toxic epidermalnecrolysis: case report
Erythema multiforme and toxic epidermal necrolysis (TEN)developed in a 19-year-old woman 14 days after she startedcarbamazepine 600 mg/day for epilepsy.
Carbamazepine was discontinued and oral prednisolonewas started. However, TEN progressed to involve 60% of thebody surface, thus plasmapheresis was started. The activity oftoxic epidermal necrolysis was reduced during plasmapheresisbut increased again after it was stopped. Gammaglobulin wasthen given for 5 days; during this time extensive re-epithelialisation occurred.
Authors comment: Investigations of this case suggest thatthe pathogenesis of erythema multiforme and toxic epidermalnecrolysis may involve a combination of immunehypersensitivity reactions and reactions mediated by toxicintermediates generated by impaired or altered drugmetabolism.Friedmann PS, et al. Investigation of mechanisms in toxic epidermal necrolysisinduced by carbamazepine. Archives of Dermatology 130: 598-604, May 1994 -England 800270961
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Reactions 2 Jul 1994 No. 5080114-9954/10/0508-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
