Carbamazepine
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Reactions 482 - 18 Dec 1993 Carbamazepine Reversible heart block in an infant: case report A reversible cardiac conduction disturbance was detected in a 13-month-old boy with tuberous sclerosis and cardiac rhabdomyoma 2 weeks after beginning carbamazepine 12 mg/kg/day for complex partial seizures. At this time, ECG and Holter monitor studies showed a predominantly normal sinus rhythm with periods of second- degree atrioventricular block and occasional premature ventricular beats. His carbamazepine level was 6 µg/L (therapeutic range 4–12 µg/ml). Carbamazepine was discontinued and replaced by valproic acid which continued to control seizures. The cardiac conduction abnormalities quickly resolved and repeat ECG’s at 6 months and 2 years appeared normal. Author comment: ‘The occurrence of cardiac conduction abnormality in a child with therapeutic CBZ [carbamazepine] levels has not been previously reported.’ This adverse effect has, however, been reported in 1 other child who had a carbamazepine level of 39 µg/ml. The cardiac tumour present in this latest case may have predisposed to the cardiac conduction abnormality. Weig SG, et al. Carbamazepine-induced heart block in a child with tuberous sclerosis and cardiac rhabdomyoma: implications for evaluation and follow-up. Annals of Neurology 34: 617-619, Oct 1993 - USA 800224444 1 Reactions 18 Dec 1993 No. 482 0114-9954/10/0482-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 482 - 18 Dec 1993
Carbamazepine
Reversible heart block in an infant: case reportA reversible cardiac conduction disturbance was detected in
a 13-month-old boy with tuberous sclerosis and cardiacrhabdomyoma 2 weeks after beginning carbamazepine 12mg/kg/day for complex partial seizures.
At this time, ECG and Holter monitor studies showed apredominantly normal sinus rhythm with periods of second-degree atrioventricular block and occasional prematureventricular beats. His carbamazepine level was 6 µg/L(therapeutic range 4–12 µg/ml).
Carbamazepine was discontinued and replaced by valproicacid which continued to control seizures. The cardiacconduction abnormalities quickly resolved and repeat ECG’s at6 months and 2 years appeared normal.
Author comment: ‘The occurrence of cardiac conductionabnormality in a child with therapeutic CBZ [carbamazepine]levels has not been previously reported.’ This adverse effect has,however, been reported in 1 other child who had acarbamazepine level of 39 µg/ml. The cardiac tumour presentin this latest case may have predisposed to the cardiacconduction abnormality.Weig SG, et al. Carbamazepine-induced heart block in a child with tuberoussclerosis and cardiac rhabdomyoma: implications for evaluation and follow-up.Annals of Neurology 34: 617-619, Oct 1993 - USA 800224444
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Reactions 18 Dec 1993 No. 4820114-9954/10/0482-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
