Carbamazepine
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Reactions 451 - 15 May 1993 Carbamazepine Hyponatraemia in a patient with diabetes insipidus: case report Hyponatraemia was identified in a 51-year-old man who had received carbamazepine 400 mg/day for 8 years for the treatment of lower back pain and headache. His plasma sodium levels returned to normal when carbamazepine was withdrawn, but fell again with carbamazepine rechallenge. He also complained of severe headache and lethargy during rechallenge. Subsequently, the patient was diagnosed with partial central diabetes insipidus based on his response to water restriction and administration of nasal desmopressin. Author comment: On the basis of the rechallenge test, carbamazepine was thought to be responsible for the hyponatraemia in this patient. ‘It is known that chlorpromazine can cause hyponatremia even in patients with central diabetes insipidus, but there has been no previous report of carbamazepine doing so.’ Kamiyama T, et al. Carbamazepine-induced hyponatremia in a patient with partial central diabetes insipidus. Nephron 64: 142-145, May 1993 - Japan 800197321 1 Reactions 15 May 1993 No. 451 0114-9954/10/0451-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 451 - 15 May 1993
Carbamazepine
Hyponatraemia in a patient with diabetes insipidus:case report
Hyponatraemia was identified in a 51-year-old man who hadreceived carbamazepine 400 mg/day for 8 years for thetreatment of lower back pain and headache. His plasmasodium levels returned to normal when carbamazepine waswithdrawn, but fell again with carbamazepine rechallenge. Healso complained of severe headache and lethargy duringrechallenge. Subsequently, the patient was diagnosed withpartial central diabetes insipidus based on his response towater restriction and administration of nasal desmopressin.
Author comment: On the basis of the rechallenge test,carbamazepine was thought to be responsible for thehyponatraemia in this patient. ‘It is known thatchlorpromazine can cause hyponatremia even in patients withcentral diabetes insipidus, but there has been no previousreport of carbamazepine doing so.’Kamiyama T, et al. Carbamazepine-induced hyponatremia in a patient with partialcentral diabetes insipidus. Nephron 64: 142-145, May 1993 - Japan 800197321
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Reactions 15 May 1993 No. 4510114-9954/10/0451-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
