Carbamazepine
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Reactions 1228 - 15 Nov 2008 Carbamazepine Alopecia and psoriasiform eruptions: case report A 52-year-old woman developed alopecia and palmoplantar psoriasiform eruptions during treatment with carbamazepine for facial pain. The woman began receiving carbamazepine 200mg three times daily for severe facial pain. One month later, she was diagnosed with acoustic schwannoma, and began experiencing psoriasiform eruptions on her soles and palms. After another month, she began developing alopecia, then presented 1 month later. A physical examination revealed diffuse hair loss on the scalp and the palmoplantar areas exhibited thick hyperkeratotic plaques. A hair-pull test showed easy hair extraction. The woman’s carbamazepine dosage was reduced to 200mg once daily after carbamazepine was suspected of inducing the symptoms. One week after dosage tapering, the psoriasiform eruptions began improving. The palmoplantar lesions also began resolving, and 4 weeks after the dosage decrease, her alopecia regressed. She underwent surgery for the acoustic schwannoma 2 months later. After stopping the carbamazepine, she experienced spontaneous hair regrowth and resolution of the skin eruptions. Author comment: "Since the suspected drug reactions in our patient improved immediately after the tapering of medication, carbamazepine should be considered a possible causative agent of hair loss and palmoplantar psoriasiform eruptions." Oh SH, et al. Concurrence of palmoplantar psoriasiform eruptions and hair loss during carbamazepine treatment. Acta Dermato-Venereologica 88: 532-533, No. 5, 2008 - South Korea 801124469 1 Reactions 15 Nov 2008 No. 1228 0114-9954/10/1228-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1228 - 15 Nov 2008
Carbamazepine
Alopecia and psoriasiform eruptions: case reportA 52-year-old woman developed alopecia and palmoplantar
psoriasiform eruptions during treatment with carbamazepinefor facial pain.
The woman began receiving carbamazepine 200mg threetimes daily for severe facial pain. One month later, she wasdiagnosed with acoustic schwannoma, and beganexperiencing psoriasiform eruptions on her soles and palms.After another month, she began developing alopecia, thenpresented 1 month later. A physical examination revealeddiffuse hair loss on the scalp and the palmoplantar areasexhibited thick hyperkeratotic plaques. A hair-pull test showedeasy hair extraction.
The woman’s carbamazepine dosage was reduced to 200mgonce daily after carbamazepine was suspected of inducing thesymptoms. One week after dosage tapering, the psoriasiformeruptions began improving. The palmoplantar lesions alsobegan resolving, and 4 weeks after the dosage decrease, heralopecia regressed. She underwent surgery for the acousticschwannoma 2 months later. After stopping thecarbamazepine, she experienced spontaneous hair regrowthand resolution of the skin eruptions.
Author comment: "Since the suspected drug reactions inour patient improved immediately after the tapering ofmedication, carbamazepine should be considered a possiblecausative agent of hair loss and palmoplantar psoriasiformeruptions."Oh SH, et al. Concurrence of palmoplantar psoriasiform eruptions and hair lossduring carbamazepine treatment. Acta Dermato-Venereologica 88: 532-533, No. 5,2008 - South Korea 801124469
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Reactions 15 Nov 2008 No. 12280114-9954/10/1228-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
