Carbamazepine
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Reactions 1343 - 19 Mar 2011 S Carbamazepine Anticonvulsant hypersensitivity syndrome: case report A 31-year-old woman developed anticonvulsant hypersensitivity syndrome (AHS) during treatment with carbamazepine. The woman started receiving carbamazepine for epilepsy [route and dosage not stated] and, 7 weeks later, she developed generalised erythema with pruritus and oedema. Despite treatment with antibiotics, her symptoms deteriorated and she subsequently presented with a 5-day history of facial puffiness, skin redness, and high fever. On admission, skin examination revealed diffuse erythema to more than 90% body surface area. Additionally, it was noted that she had green staining in her underpants and axillary part of her undershirt. Blood cultures revealed Pseudomonas aeruginosa. She was diagnosed with carbamazepine-dependent AHS based on laboratory findings and clinical history. Carbamazepine was discontinued, and the woman received topical treatment of the erythroderma and systemic antihistamines for her pruritus. She received cefepime and her fever improved within 72 hours. By the end of the second week of treatment, her dermatologic symptoms had improved. Her blood counts normalised and her antibiotic therapy was stopped on day 14 of hospitalisation. Author comment: "Anticonvulsant hypersensitivity syndrome is a nondose-related idiosyncratic reaction to aromatic antiepileptic drugs and is a cause of drug discontinuation." Yilmaz E, et al. Green staining of clothing: a signal for pseudomonal infection. Cutis 86: 305-8, No. 6, Dec 2010 - Turkey 803051428 1 Reactions 19 Mar 2011 No. 1343 0114-9954/10/1343-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1343 - 19 Mar 2011
SCarbamazepine
Anticonvulsant hypersensitivity syndrome: casereport
A 31-year-old woman developed anticonvulsanthypersensitivity syndrome (AHS) during treatment withcarbamazepine.
The woman started receiving carbamazepine for epilepsy[route and dosage not stated] and, 7 weeks later, shedeveloped generalised erythema with pruritus andoedema. Despite treatment with antibiotics, her symptomsdeteriorated and she subsequently presented with a 5-dayhistory of facial puffiness, skin redness, and high fever. Onadmission, skin examination revealed diffuse erythema tomore than 90% body surface area. Additionally, it wasnoted that she had green staining in her underpants andaxillary part of her undershirt. Blood cultures revealedPseudomonas aeruginosa. She was diagnosed withcarbamazepine-dependent AHS based on laboratoryfindings and clinical history.
Carbamazepine was discontinued, and the womanreceived topical treatment of the erythroderma andsystemic antihistamines for her pruritus. She receivedcefepime and her fever improved within 72 hours. By theend of the second week of treatment, her dermatologicsymptoms had improved. Her blood counts normalisedand her antibiotic therapy was stopped on day 14 ofhospitalisation.
Author comment: "Anticonvulsant hypersensitivitysyndrome is a nondose-related idiosyncratic reaction toaromatic antiepileptic drugs and is a cause of drugdiscontinuation."Yilmaz E, et al. Green staining of clothing: a signal for pseudomonal infection.Cutis 86: 305-8, No. 6, Dec 2010 - Turkey 803051428
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Reactions 19 Mar 2011 No. 13430114-9954/10/1343-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
