Carbamazepine
1
Reactions 1412 - 28 Jul 2012 Carbamazepine Hyperammonaemia and asterixis: case report A 30-year-old woman with bipolar disorder developed hyperammonaemia and asterixis following treatment with carbamazepine. The woman developed impaired sensorium and jerks in both upper limbs with asterixis within 2 weeks of achieving a therapeutic dose of carbamazepine of 600mg [dosing frequency, route and therapeutic indication not stated]. Laboratory tests were within normal limits except for an elevated serum ammonia level of 119 Umol/L. No alternative contributory comorbidity or concomitant medication was identified. Carbamazepine was tapered then discontinued. The woman’s symptoms of jerks in her upper limbs with asterixis reduced and she regained her sensorium. Her serum ammonia level subsequently decreased to 47 Umol/L (normal range 11–35 Umol/L). Author comment: "We report a case of carbamazepine induced hyperammonemia with asterixis". Singh H, et al. Carbamazepine induced hyperammonemia and asterixis a case report and review of literature. Indian Journal of Psychiatry 53 (Suppl. 1): 78, No. 5, Apr 2011 [Abstract] - India 803073404 1 Reactions 28 Jul 2012 No. 1412 0114-9954/10/1412-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1412 - 28 Jul 2012
Carbamazepine
Hyperammonaemia and asterixis: case reportA 30-year-old woman with bipolar disorder developed
hyperammonaemia and asterixis following treatment withcarbamazepine.
The woman developed impaired sensorium and jerks inboth upper limbs with asterixis within 2 weeks of achievinga therapeutic dose of carbamazepine of 600mg [dosingfrequency, route and therapeutic indication not stated].Laboratory tests were within normal limits except for anelevated serum ammonia level of 119 Umol/L. Noalternative contributory comorbidity or concomitantmedication was identified.
Carbamazepine was tapered then discontinued. Thewoman’s symptoms of jerks in her upper limbs withasterixis reduced and she regained her sensorium. Herserum ammonia level subsequently decreased to47 Umol/L (normal range 11–35 Umol/L).
Author comment: "We report a case of carbamazepineinduced hyperammonemia with asterixis".Singh H, et al. Carbamazepine induced hyperammonemia and asterixis a casereport and review of literature. Indian Journal of Psychiatry 53 (Suppl. 1): 78, No.5, Apr 2011 [Abstract] - India 803073404
1
Reactions 28 Jul 2012 No. 14120114-9954/10/1412-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
