Carbamazepine
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Reactions 930 - 30 Nov 2002 Carbamazepine Antibody deficiency: case report A 45-year-old woman with epilepsy developed antibody deficiency during treatment with carbamazepine. The woman had been receiving carbamazepine [dosage not stated] for approximately 4 years when she presented with an 8-month history of recurrent upper respiratory tract infections that required antibacterial therapy. Repeated measurements of serum immunoglobulins revealed antibody deficiency, with decreased levels of IgG (4.5 g/L, normal 6–16), IgM (0.3 g/L, 0.5–2) and IgA (0.67 g/L, 0.8–2.8). She was treated with prophylactic antibacterials and monitored for several months. The woman stopped taking carbamazepine and, 3 months later, her IgG levels had increased to 6.1 g/L, although her IgM and IgA levels remained low at 0.22 and 0.74 g/L, respectively. Seven months after stopping carbamazepine, her IgG, IgM and IgA levels were near normal at 7.5, 0.33 and 0.89 g/L, respectively. At this time, she had no active infections and prophylactic antibacterials were withdrawn without incident. Hayman G, et al. Antibody deficiency associated with carbamazepine. BMJ 325: 1213, 23 Nov 2002 - England 800925005 1 Reactions 30 Nov 2002 No. 930 0114-9954/10/0930-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 930 - 30 Nov 2002
Carbamazepine
Antibody deficiency: case reportA 45-year-old woman with epilepsy developed antibody
deficiency during treatment with carbamazepine.The woman had been receiving carbamazepine [dosage not
stated] for approximately 4 years when she presented with an8-month history of recurrent upper respiratory tract infectionsthat required antibacterial therapy. Repeated measurements ofserum immunoglobulins revealed antibody deficiency, withdecreased levels of IgG (4.5 g/L, normal 6–16), IgM (0.3 g/L,0.5–2) and IgA (0.67 g/L, 0.8–2.8). She was treated withprophylactic antibacterials and monitored for several months.
The woman stopped taking carbamazepine and, 3 monthslater, her IgG levels had increased to 6.1 g/L, although her IgMand IgA levels remained low at 0.22 and 0.74 g/L, respectively.Seven months after stopping carbamazepine, her IgG, IgM andIgA levels were near normal at 7.5, 0.33 and 0.89 g/L,respectively. At this time, she had no active infections andprophylactic antibacterials were withdrawn without incident.Hayman G, et al. Antibody deficiency associated with carbamazepine. BMJ 325:1213, 23 Nov 2002 - England 800925005
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Reactions 30 Nov 2002 No. 9300114-9954/10/0930-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
