Carbamazepine
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Reactions 728 - 21 Nov 1998 Carbamazepine Abnormal pitch perception: case report A 16-year-old girl reported lowering in her perceived pitch of sounds 3 days after she started carbamazepine 200 mg/day for epilepsy. The girl noted lowered pitch of the ring of a telephone, music and other everyday sounds. Two weeks later, after her carbamazepine dosage was increased to 300 mg/day, she developed tinnitus. She denied decreased hearing ablility, although no formal audiological tests were performed. Four weeks later, she still had auditory disturbances. At this time, her serum concentration of carbamazepine was 4.3 µg/ml. Carbamazepine was stopped and replaced with zonisamide. The girl’s auditory symptoms resolved 2 days later. Author comment: ‘Because auditory disturbance may occur at a therapeutic serum level of CBZ [carbamazepine], heightened awareness of reversible hearing impairment upon starting CBZ is important, especially when treating younger patients who may not complain of the symptom.’ Kashihara K, et al. Reversible pitch perception deficit due to carbamazepine. Internal Medicine 37: 774-775, Sep 1998 - Japan 800720374 1 Reactions 21 Nov 1998 No. 728 0114-9954/10/0728-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 728 - 21 Nov 1998
Carbamazepine
Abnormal pitch perception: case reportA 16-year-old girl reported lowering in her perceived pitch
of sounds 3 days after she started carbamazepine 200 mg/dayfor epilepsy.
The girl noted lowered pitch of the ring of a telephone,music and other everyday sounds. Two weeks later, after hercarbamazepine dosage was increased to 300 mg/day, shedeveloped tinnitus. She denied decreased hearing ablility,although no formal audiological tests were performed. Fourweeks later, she still had auditory disturbances. At this time,her serum concentration of carbamazepine was 4.3 µg/ml.
Carbamazepine was stopped and replaced with zonisamide.The girl’s auditory symptoms resolved 2 days later.
Author comment: ‘Because auditory disturbance may occurat a therapeutic serum level of CBZ [carbamazepine],heightened awareness of reversible hearing impairment uponstarting CBZ is important, especially when treating youngerpatients who may not complain of the symptom.’Kashihara K, et al. Reversible pitch perception deficit due to carbamazepine.Internal Medicine 37: 774-775, Sep 1998 - Japan 800720374
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Reactions 21 Nov 1998 No. 7280114-9954/10/0728-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
