Benazepril/hydrochlorothiazide/oxcarbazepine overdose
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Reactions 1104 - 3 Jun 2006 O S Benazepril/hydrochlorothiazide/ oxcarbazepine overdose Unconsciousness: case report A 57-year-old man with epilepsy and hypertension ingested an overdose of oxcarbazepine [Tolep] and benazepril/hydrochlorothiazide [Cipadrex], along with ethanol, and subsequently became unconscious. At dinner, the man ingested approximately 70 tablets of oxcarbazepine 600mg and an undefined number of benazepril/hydrochlorothiazide 10mg/12.5mg tablets with some glasses of wine and, 4 hours later, he was brought to the emergency room. He was confused. He had a BP of 150/90mm Hg and an HR of 60 beats/min. Activated charcoal and a saline laxative were administered. Laboratory investigations showed mild hypokalaemia and a blood alcohol concentration of 200 mg/dL. The man was hospitalised. He gradually became unconscious (Glasgow Coma Scale score of 7); he was intubated and transferred to the ICU. Approximately 6 hours after ingestion of the overdose, his serum concentrations of oxcarbazepine and monohydroxycarbazepine were 12.45 and 65.45 µg/mL, respectively. He underwent 4 hours of haemodialysis, 3 hours following which, he had completely recovered and was discharged from the ICU. Furlanut M, et al. Acute oxcarbazepine, benazepril, and hydrochlorothiazide overdose with alchohol. Therapeutic Drug Monitoring 28: 267-268, No. 2, Apr 2006 - Italy 801064313 1 Reactions 3 Jun 2006 No. 1104 0114-9954/10/1104-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Benazepril/hydrochlorothiazide/oxcarbazepine overdose
Reactions 1104 - 3 Jun 2006
O SBenazepril/hydrochlorothiazide/oxcarbazepine overdose
Unconsciousness: case reportA 57-year-old man with epilepsy and hypertension ingested
an overdose of oxcarbazepine [Tolep] andbenazepril/hydrochlorothiazide [Cipadrex], along withethanol, and subsequently became unconscious.
At dinner, the man ingested approximately 70 tablets ofoxcarbazepine 600mg and an undefined number ofbenazepril/hydrochlorothiazide 10mg/12.5mg tablets withsome glasses of wine and, 4 hours later, he was brought to theemergency room. He was confused. He had a BP of150/90mm Hg and an HR of 60 beats/min.
Activated charcoal and a saline laxative were administered.Laboratory investigations showed mild hypokalaemia and ablood alcohol concentration of 200 mg/dL. The man washospitalised. He gradually became unconscious (GlasgowComa Scale score of 7); he was intubated and transferred tothe ICU. Approximately 6 hours after ingestion of theoverdose, his serum concentrations of oxcarbazepine andmonohydroxycarbazepine were 12.45 and 65.45 µg/mL,respectively. He underwent 4 hours of haemodialysis, 3 hoursfollowing which, he had completely recovered and wasdischarged from the ICU.Furlanut M, et al. Acute oxcarbazepine, benazepril, and hydrochlorothiazideoverdose with alchohol. Therapeutic Drug Monitoring 28: 267-268, No. 2, Apr2006 - Italy 801064313
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Reactions 3 Jun 2006 No. 11040114-9954/10/1104-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
