Antineoplastics
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Reactions 473 - 16 Oct 1993 Antineoplastics Sexual function disorders in adolescents: incidence study An Indian study found that severe damage to germinal epithelium occurred in adolescent boys with Hodgkin’s disease who received antineoplastic therapy during prepubertal development. 26 boys (median age 12 years) were treated with at least 3 cycles of combination therapy with COPP or MOPP. MOPP therapy comprised mechlorethamine, prednisolone, procarbazine, and vincristine, while in the COPP regimen, cyclophosphamide replaced mechlorethamine. Gonadal functions, including gonadal function history, semen analysis, and hormonal assays, were assessed after the development of secondary sexual characteristics. Results showed azoospermia and elevated follicle- stimulating hormone and inhibin production in 18/26 evaluable patients. Damage to seminiferous tubules was identified in testicular biopsies from 2 patients. Dhabhar BN, et al. Gonadal function in prepubertal boys following treatment for Hodgkin’s disease. American Journal of Pediatric Hematology Oncology 15: 306-310, Aug 1993 - India 807033331 1 Reactions 16 Oct 1993 No. 473 0114-9954/10/0473-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 473 - 16 Oct 1993
Antineoplastics
Sexual function disorders in adolescents: incidencestudy
An Indian study found that severe damage to germinalepithelium occurred in adolescent boys with Hodgkin’sdisease who received antineoplastic therapy duringprepubertal development.
26 boys (median age 12 years) were treated with at least 3cycles of combination therapy with COPP or MOPP. MOPPtherapy comprised mechlorethamine, prednisolone,procarbazine, and vincristine, while in the COPP regimen,cyclophosphamide replaced mechlorethamine. Gonadalfunctions, including gonadal function history, semen analysis,and hormonal assays, were assessed after the development ofsecondary sexual characteristics.
Results showed azoospermia and elevated follicle-stimulating hormone and inhibin production in 18/26evaluable patients. Damage to seminiferous tubules wasidentified in testicular biopsies from 2 patients.Dhabhar BN, et al. Gonadal function in prepubertal boys following treatment forHodgkin’s disease. American Journal of Pediatric Hematology Oncology 15:306-310, Aug 1993 - India 807033331
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Reactions 16 Oct 1993 No. 4730114-9954/10/0473-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
