Antineoplastics
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Antineoplastics First report of myeloblastic N5!J leukaemia after bone marrow transplant: case report After diagnosis of immature ovarian teratoma, a 15-year-old girl received 4 courses of chemotherapy with doxorubicin, cyclophosphamide and cisplatin . The patient then received inte ns ification treatment 3 weeks later, with cyclophosph am ide and total body irradiation, followed by bone marrow rescue . E ight months later, myelomonocytic acute leukaemia was diagnosed. After treatment with hydroxycarbamide, the patient improved transiently but died later of cerebral bleeding after refusing further chemotherapy. To the authors ' knowledge, th is was " , , the first reported case of leukaemia after autologous bone marrow transplantation '. Guyotat D. COlffler B Campos L. Archlmbaud E. Treille D. el al Acute leukaemia follOWing high· dose chemoradlotherapy With bone marrow resc ue for ovarian teraloma Acta Haematologlca 80 52·53 No 1. 1988 "" Pulmonary embolism: 5 case [iJ reports 187 patients, with histologically proven non-Hodgkin's lymphoma, received up to seven 28-day cycles of chemotherapy, comprising cyclophosphamide, doxo rubicin , procarbazine, bleomycin, vincristine and prednisone. Five patients, successfully treated or in unmaintained complete remission after chemotherapy, were found to have pulmonary embolism. Two patients died and 3 were treated with anticoagulant therapy. A further 18 patients deve loped pulmonary problems, the causes of which were not identified. 'In patients receiving chemotherapy for lymphomas or other malignancies who present with respiratory difficultIes, we recommend a careful history and physical examination, arterial blood gas values, and a chest x-ray film be obtained.' Glenn LD, Armitage JO. Goldsmith JC. Sorensen S. Howe D, et al Pulmonary emboli In patients receiving chemotherapy for non·Hodgkln's lymphoma Chest 94 589,594 , Sep 1988 [46 references 1 7 ." Erythema and swelling: 5 case reports Shall L, Lucas GS , Whittaker JA. Holt PJ A Painful red hands a slde·effect of leukaemia therapy British Journal of Dermatology 119 249·253, Aug 1988 " ,. 0157-7271 / 88/ 1015-0005/ 0$01 .00/ 0 © ADIS Press Lung abscess and bronchopleural [iJ fistula: 7 case reports Frytak S . Lee RE . Panolero PC Arnold PG . Show IN Necrotic lung and bronchopleural fistula as complications of therapy In lung cancer Cancer Investigation 62 139·1 43 . No 2. 1988 " 50 REACT/ONse 15 Oct 1988 5
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Transcript of Antineoplastics
Antineoplastics ~t,f$1 First report of myeloblastic N5!J
leukaemia after bone marrow transplant: case report
After diagnosis of immature ovarian teratoma, a 15-year-old girl received 4 courses of chemotherapy with doxorubicin , cyclophosphamide and cisplatin . The patient then received intensification treatment 3 weeks later , with cyclophosphamide and total body irradiation, followed by bone marrow rescue. Eight months later, myelomonocytic acute leukaemia was diagnosed. After treatment with hydroxycarbamide, the patient improved transiently but died later of cerebral bleeding after refusing further chemotherapy.
To the authors ' knowledge, th is was " , , the first reported case of leukaemia after autologous bone marrow transplantation '.
Guyotat D. COlffler B Campos L. Archlmbaud E. Treille D. el al Acute leukaemia follOWing high· dose chemoradlotherapy With bone marrow rescue for ovarian teraloma Acta Haematologlca
80 52·53 No 1. 1988 " "
Pulmonary embolism: 5 case [iJ reports
187 patients , with histologically proven non-Hodgkin 's lymphoma, received up to seven 28-day cycles of chemotherapy, comprising cyclophosphamide, doxorubicin , procarbazine, bleomycin , vincristine and prednisone. Five patients, successfully treated or in unmaintained complete remission after chemotherapy, were found to have pulmonary embolism. Two patients died and 3 were treated with anticoagulant therapy. A further 18 patients developed pulmonary problems , the causes of which were not identified.
'In patients receiving chemotherapy for lymphomas or other malignancies who present with respiratory difficultIes, we recommend a careful history and physical examination, arterial blood gas values, and a chest x-ray film be obtained.'
Glenn LD, Armitage JO. Goldsmith JC. Sorensen S. Howe D, et al Pulmonary emboli In patients receiving chemotherapy for non·Hodgkln 's lymphoma Chest 94 589,594, Sep 1988 [46 references 1 7."
Erythema and swelling: 5 case reports Shall L, Lucas GS , Whittaker JA. Holt PJA Painful red hands a slde·effect of leukaemia therapy British Journal of Dermatology 119 249·253, Aug 1988 " ,.
0157-7271 / 88/ 1015-0005/ 0$01 .00/ 0 © ADIS Press
Lung abscess and bronchopleural [iJ fistula: 7 case reports Frytak S . Lee RE . Panolero PC Arnold PG . Show IN Necrotic lung and bronchopleural fistula as complications of therapy In lung cancer Cancer Investigation 62 139·1 43. No 2. 1988 " 50
REACT/ONse 15 Oct 1988 5
