Antineoplastics
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Reactions 1428 - 17 Nov 2012 S Antineoplastics Gastrointestinal upset and myocardial injuries: case report A 62-year-old woman developed gastrointestinal upset and myocardial injuries during treatment with antineoplastics [routes not stated]. The woman had been diagnosed initially with gastric antral cancer. Later, she was diagnosed with light-chain (AL) amyloidosis with gastrointestinal and skin involvement. After the discovery of marrow plasmacytosis, it was concluded that she had multiple myeloma associated with AL amyloidosis. After the diagnosis of multiple myeloma, she was started on a chemotherapy regimen with cyclophosphamide, vindesine, pirarubicin and dexamethasone. On the first day, she was scheduled to receive cyclophosphamide 800mg and vindesine 3mg. On days 1 and 2, she was scheduled to receive pirarubicin 20 mg/day. On days 1 to 5, she was to receive dexamethasone 20 mg/day. The woman developed myocardial injuries and gastrointestinal upset due to antineoplastic toxicity [duration of treatment to reaction onset not clearly stated]. She developed cardiorespiratory arrest on the third day of chemotherapy and also developed grave metabolic acidosis. Her renal and hepatic functions declined as well. She died from multiple organ failure. Author comment: "Unfortunately, because of chemotherapeutic toxicity, the patient suffered from serious gastrointestinal upset and myocardial injuries." Liu W, et al. Multiple myeloma associated with light-chain amyloidosis manifesting as gastric retention: A case report and review of the literature. West Indian Medical Journal 60: 681-684, No. 6, Dec 2011 - China 803079854 1 Reactions 17 Nov 2012 No. 1428 0114-9954/10/1428-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1428 - 17 Nov 2012
SAntineoplastics
Gastrointestinal upset and myocardial injuries:case report
A 62-year-old woman developed gastrointestinal upsetand myocardial injuries during treatment withantineoplastics [routes not stated].
The woman had been diagnosed initially with gastricantral cancer. Later, she was diagnosed with light-chain(AL) amyloidosis with gastrointestinal and skininvolvement. After the discovery of marrow plasmacytosis,it was concluded that she had multiple myeloma associatedwith AL amyloidosis. After the diagnosis of multiplemyeloma, she was started on a chemotherapy regimenwith cyclophosphamide, vindesine, pirarubicin anddexamethasone. On the first day, she was scheduled toreceive cyclophosphamide 800mg and vindesine 3mg. Ondays 1 and 2, she was scheduled to receive pirarubicin20 mg/day. On days 1 to 5, she was to receivedexamethasone 20 mg/day.
The woman developed myocardial injuries andgastrointestinal upset due to antineoplastic toxicity[duration of treatment to reaction onset not clearly stated].She developed cardiorespiratory arrest on the third day ofchemotherapy and also developed grave metabolicacidosis. Her renal and hepatic functions declined as well.She died from multiple organ failure.
Author comment: "Unfortunately, because ofchemotherapeutic toxicity, the patient suffered from seriousgastrointestinal upset and myocardial injuries."Liu W, et al. Multiple myeloma associated with light-chain amyloidosismanifesting as gastric retention: A case report and review of the literature. WestIndian Medical Journal 60: 681-684, No. 6, Dec 2011 - China 803079854
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Reactions 17 Nov 2012 No. 14280114-9954/10/1428-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
