Antineoplastics
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Reactions 1389 - 18 Feb 2012 S Antineoplastics Sinus thrombosis, osteopenia aggravation and liver toxicity in a child: case report A 10-year-old boy developed sinus thrombosis, aggravation of osteopenia and liver toxicity while receiving antineoplastics. The boy, who had a history of cystic fibrosis (CF) with intermittent Pseudomonas aeruginosa infections and osteopenia, was diagnosed with acute lymphoblastic leukaemia (ALL). He received chemotherapy according to the ALL-BFM 2000 protocol (amendment 2006-07-01), that included prednisone, asparaginase and dexamethasone 10 mg/m 2 /day [dosage information incomplete; routes not stated]. During therapy, he developed cerebral venous thrombosis of the superior sagittal sinus after administration of asparaginase. He also developed aggravated osteopenia with severe back pain, with liver toxicity occurring during protocol II/1 of chemotherapy [specific drugs and duration of treatment to reaction onsets not stated]. The boy’s aggravated osteopenia resulted in the requirement for a wheelchair, as well as administration of morphine, calcium and bisphosphonates. After the onset of liver toxicity, chemotherapy was withheld. [Patient outcome not stated]. Author comment: "[T]he applied high-dose steroid therapy presumably aggravated the pre-existing CF-related osteopenia." Dopfer C, et al. Acute lymphoblastic leukemia in a 10-year-old boy with cystic fibrosis-improvement of pulmonary function during chemotherapy in spite of intermittent Pseudomonas aeruginosa colonisation. Klinische Padiatrie 223: 368-369, No. 6, Nov 2011. Available from: URL: http://dx.doi.org/10.1055/ s-0031-1285880 - Germany 803066946 1 Reactions 18 Feb 2012 No. 1389 0114-9954/10/1389-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1389 - 18 Feb 2012
SAntineoplastics
Sinus thrombosis, osteopenia aggravation andliver toxicity in a child: case report
A 10-year-old boy developed sinus thrombosis,aggravation of osteopenia and liver toxicity while receivingantineoplastics.
The boy, who had a history of cystic fibrosis (CF) withintermittent Pseudomonas aeruginosa infections andosteopenia, was diagnosed with acute lymphoblasticleukaemia (ALL). He received chemotherapy according tothe ALL-BFM 2000 protocol (amendment 2006-07-01), thatincluded prednisone, asparaginase and dexamethasone10 mg/m2/day [dosage information incomplete; routes notstated]. During therapy, he developed cerebral venousthrombosis of the superior sagittal sinus afteradministration of asparaginase. He also developedaggravated osteopenia with severe back pain, with livertoxicity occurring during protocol II/1 of chemotherapy[specific drugs and duration of treatment to reaction onsetsnot stated].
The boy’s aggravated osteopenia resulted in therequirement for a wheelchair, as well as administration ofmorphine, calcium and bisphosphonates. After the onset ofliver toxicity, chemotherapy was withheld. [Patientoutcome not stated].
Author comment: "[T]he applied high-dose steroid therapypresumably aggravated the pre-existing CF-relatedosteopenia."Dopfer C, et al. Acute lymphoblastic leukemia in a 10-year-old boy with cysticfibrosis-improvement of pulmonary function during chemotherapy in spite ofintermittent Pseudomonas aeruginosa colonisation. Klinische Padiatrie 223:368-369, No. 6, Nov 2011. Available from: URL: http://dx.doi.org/10.1055/s-0031-1285880 - Germany 803066946
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Reactions 18 Feb 2012 No. 13890114-9954/10/1389-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
