Antineoplastics
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Reactions 1413 - 4 Aug 2012 S Antineoplastics Mucoepidermoid carcinoma of the parotid gland as a second cancer in a child: case report An 8-year-old girl developed mucoepidermoid carcinoma of the parotid gland as a second cancer after receiving antineoplastics for acute lymphoid leukaemia (ALL) according to the Berlin-Frankfurt-Munster 2000 protocol. The girl was diagnosed with pro-B ALL at 2 6/12 years old in May 2002, and received induction and consolidation therapy with vincristine, cyclophosphamide, asparaginase, prednisone, doxorubicin, methotrexate and cytarabine, followed by prophylactic cranial radiotherapy (12Gy), and then maintenance therapy with mercaptopurine and intrathecal methotrexate [not all routes stated; dosages not stated]. She was in remission after her chemotherapy was discontinued in July 2004. A retroauricular mass was found when she was 8 years old, 65 months after the initial diagnosis, and 3 years after chemotherapy completion. The girl underwent parotidectomy. Mucoepidermoid carcinoma was diagnosed, and histopathology showed cystic component of 30%, 2 mitotic figures per 10 high- powerfields, lack of neural involvement, necrosis, and anaplasia. A second surgery was performed 3 months after the first operation because of recurrent mass in the primary tumour area. A third surgery, a radical neck dissection with excision, was performed 2 months later. Mucoepidermoid tumour infiltration in soft tissue sample, salivary glands and around the facial nerve was still evident in May 2008. She also developed facial nerve paralysis. Radiotherapy was applied to her left parotid area, and on 4 years’ follow-up, she neither had mass nor any complaints. Author comment: "Second cancers in childhood may be related to genetic predisposition, but most of them are attributed to irradiation and/or multidrug chemotherapy." Tugcu D, et al. Mucoepidermoid carcinoma of the parotid gland in childhood survivor of acute lymphoblastic leukemia with need of radiotherapy for treatment and review of the literature. Pediatric Hematology and Oncology 29: 380-385, No. 4, May 2012. Available from: URL: http:// dx.doi.org/10.3109/08880018.2012.673696 - Turkey 803074568 1 Reactions 4 Aug 2012 No. 1413 0114-9954/10/1413-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1413 - 4 Aug 2012
SAntineoplastics
Mucoepidermoid carcinoma of the parotid glandas a second cancer in a child: case report
An 8-year-old girl developed mucoepidermoidcarcinoma of the parotid gland as a second cancer afterreceiving antineoplastics for acute lymphoid leukaemia(ALL) according to the Berlin-Frankfurt-Munster2000 protocol.
The girl was diagnosed with pro-B ALL at 2 6/12 years oldin May 2002, and received induction and consolidationtherapy with vincristine, cyclophosphamide, asparaginase,prednisone, doxorubicin, methotrexate and cytarabine,followed by prophylactic cranial radiotherapy (12Gy), andthen maintenance therapy with mercaptopurine andintrathecal methotrexate [not all routes stated; dosages notstated]. She was in remission after her chemotherapy wasdiscontinued in July 2004. A retroauricular mass was foundwhen she was 8 years old, 65 months after the initialdiagnosis, and 3 years after chemotherapy completion.
The girl underwent parotidectomy. Mucoepidermoidcarcinoma was diagnosed, and histopathology showedcystic component of 30%, 2 mitotic figures per 10 high-powerfields, lack of neural involvement, necrosis, andanaplasia. A second surgery was performed 3 months afterthe first operation because of recurrent mass in the primarytumour area. A third surgery, a radical neck dissection withexcision, was performed 2 months later. Mucoepidermoidtumour infiltration in soft tissue sample, salivary glands andaround the facial nerve was still evident in May 2008. Shealso developed facial nerve paralysis. Radiotherapy wasapplied to her left parotid area, and on 4 years’ follow-up,she neither had mass nor any complaints.
Author comment: "Second cancers in childhood may berelated to genetic predisposition, but most of them areattributed to irradiation and/or multidrug chemotherapy."Tugcu D, et al. Mucoepidermoid carcinoma of the parotid gland in childhoodsurvivor of acute lymphoblastic leukemia with need of radiotherapy for treatmentand review of the literature. Pediatric Hematology and Oncology 29: 380-385, No.4, May 2012. Available from: URL: http://dx.doi.org/10.3109/08880018.2012.673696 - Turkey 803074568
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Reactions 4 Aug 2012 No. 14130114-9954/10/1413-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
