Antineoplastics
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Reactions 1411 - 21 Jul 2012 S Antineoplastics Various toxicities in elderly patients: 3 case reports Three elderly patients aged 75 years or older developed various toxicities resulting in death during or following chemoradiation for oesophageal cancer [sexes, routes and dosages not stated]. Patient 1 died of pulmonary haemorrhage and acute respiratory failure after receiving one cycle of cisplatin and fluorouracil, in combination with 16.2Gy of radiotherapy. Patient 2 experienced sudden death after receiving one cycle of fluorouracil in combination with 3.6Gy of radiotherapy. Patient 3 died of sepsis due to persistent neutropenia one month after completing 50.4Gy of radiotherapy and four cycles of chemotherapy with cisplatin, irinotecan and cetuximab. Author comment: "[F]ull-dose chemoradiation can cause severe toxicity in even the most healthy and functional patients older than 75 years old." Mak RH, et al. Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older. Diseases of the Esophagus 23: 316-323, No. 4, May 2010. Available from: URL: http://dx.doi.org/10.1111/j.1442-2050.2009.01014.x - USA 803074010 1 Reactions 21 Jul 2012 No. 1411 0114-9954/10/1411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 1411 - 21 Jul 2012
SAntineoplastics
Various toxicities in elderly patients: 3 casereports
Three elderly patients aged 75 years or older developedvarious toxicities resulting in death during or followingchemoradiation for oesophageal cancer [sexes, routes anddosages not stated].
Patient 1 died of pulmonary haemorrhage and acuterespiratory failure after receiving one cycle of cisplatin andfluorouracil, in combination with 16.2Gy of radiotherapy.
Patient 2 experienced sudden death after receiving onecycle of fluorouracil in combination with 3.6Gy ofradiotherapy.
Patient 3 died of sepsis due to persistent neutropenia onemonth after completing 50.4Gy of radiotherapy and fourcycles of chemotherapy with cisplatin, irinotecan andcetuximab.
Author comment: "[F]ull-dose chemoradiation can causesevere toxicity in even the most healthy and functionalpatients older than 75 years old."Mak RH, et al. Toxicity and outcomes after chemoradiation for esophageal cancerin patients age 75 or older. Diseases of the Esophagus 23: 316-323, No. 4, May2010. Available from: URL: http://dx.doi.org/10.1111/j.1442-2050.2009.01014.x -USA 803074010
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Reactions 21 Jul 2012 No. 14110114-9954/10/1411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
