Antineoplastics
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Reactions 1328 - 20 Nov 2010 ★ S Antineoplastics First report of renal cell carcinoma?: 2 case reports Two patients developed renal cell carcinoma (RCC) following treatment with either daunorubicin, doxorubicin, tretinoin, cytarabine and idarubicin for acute promyelocytic leukaemia (APL) [routes, dosages and duration of treatments prior to reaction onsets not stated]. Patient 1, a 64-year-old woman, received daunorubicin, doxorubicin and tretinoin after diagnosis with APL in July 2006. A left renal mass was observed on CT imaging, and in December 2006 the results of a nephrectomy revealed a RCC. Daunorubicin and tretinoin were initiated; colon cancer was subsequently revealed. At last observation, RCC was not detected. Patient 2, a 58-year-old man, received cytarabine, idarubicin and tretinoin; the results of a CT scan showed a new left renal mass. Idarubicin (two cycles) was initiated, and maintenance therapy with tretinoin, mercaptopurine and methotrexate was administered. A repeat CT scan revealed pulmonary nodules; tests confirmed metastatic RCC. Sunitinib was initiated, and his RCC regressed with resolution of lung metastases. Author comment: "RCC in Case 1 was detected 2 months after the diagnosis of APL. In the second case, RCC was diagnosed during the induction phase of the treatment of APL . . . Taking into account the immunology of RCC and the effect of ATRA [tretinoin] on the immune system, it is possible that ATRA or the chemotherapeutic regimen for APL has a role in the development of RCC". Parajuli R, et al. Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association?. American Journal of Hematology 85: 829, No. 10, Oct 2010 - USA 803043886 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of renal cell carcinoma associated with either daunorubicin, doxorubicin, tretinoin, cytarabine or idarubicin. The WHO ADR database contained seven reports of renal cell carcinoma associated with cytarabine, and daunorubicin, while eight reports were associated with doxorubicin. No reports of renal cell carcinoma associated with either tretinoin or idarubicin were revealed. 1 Reactions 20 Nov 2010 No. 1328 0114-9954/10/1328-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1328 - 20 Nov 2010
★ SAntineoplastics
First report of renal cell carcinoma?: 2 casereports
Two patients developed renal cell carcinoma (RCC)following treatment with either daunorubicin, doxorubicin,tretinoin, cytarabine and idarubicin for acute promyelocyticleukaemia (APL) [routes, dosages and duration oftreatments prior to reaction onsets not stated].
Patient 1, a 64-year-old woman, received daunorubicin,doxorubicin and tretinoin after diagnosis with APL in July2006. A left renal mass was observed on CT imaging, and inDecember 2006 the results of a nephrectomy revealed aRCC. Daunorubicin and tretinoin were initiated; coloncancer was subsequently revealed. At last observation, RCCwas not detected.
Patient 2, a 58-year-old man, received cytarabine,idarubicin and tretinoin; the results of a CT scan showed anew left renal mass. Idarubicin (two cycles) was initiated,and maintenance therapy with tretinoin, mercaptopurineand methotrexate was administered. A repeat CT scanrevealed pulmonary nodules; tests confirmed metastaticRCC. Sunitinib was initiated, and his RCC regressed withresolution of lung metastases.
Author comment: "RCC in Case 1 was detected 2 monthsafter the diagnosis of APL. In the second case, RCC wasdiagnosed during the induction phase of the treatment ofAPL . . . Taking into account the immunology of RCC and theeffect of ATRA [tretinoin] on the immune system, it is possiblethat ATRA or the chemotherapeutic regimen for APL has arole in the development of RCC".Parajuli R, et al. Renal cell carcinoma and acute promyelocytic leukemia: anonrandom association?. American Journal of Hematology 85: 829, No. 10, Oct2010 - USA 803043886
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of renal cellcarcinoma associated with either daunorubicin, doxorubicin,tretinoin, cytarabine or idarubicin. The WHO ADR databasecontained seven reports of renal cell carcinoma associatedwith cytarabine, and daunorubicin, while eight reports wereassociated with doxorubicin. No reports of renal cellcarcinoma associated with either tretinoin or idarubicin wererevealed.
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Reactions 20 Nov 2010 No. 13280114-9954/10/1328-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
