Antineoplastics
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Reactions 1257 - 20 Jun 2009 ★ S Antineoplastics Mucoepidermoid carcinoma (first report with busulfan and dexamethasone) as a secondary cancer: case report An adolescent boy developed a secondary mucoepidermoid carcinoma of the submandibular gland, after receiving treatment with multiple antineoplastics for acute myeloid leukaemia. After the initial diagnosis at age 5 years, the boy was administered the DCTER regimen, consisting of etoposide (cumulative dose 1600 mg/m 2 ), dexamethasone, cytarabine, tioguanine and daunorubicin [dosages not stated]. He later received cyclophosphamide (cumulative dose 120 mg/kg) and busulfan [dosage not stated], before undergoing a stem cell transplant. He achieved complete remission. Eight years after his initial diagnosis, he presented with a slow-growing, painless mass (1.5 × 2.0cm) in the left submandibular area. The mass was mobile with a smooth surface and a hard consistency. Fine- needle aspiration cytology revealed a mucoepidermoid carcinoma, and PET-CT scanning ruled out metastases. He was asymptomatic. The boy underwent a left submandibular gland excision and a left supra-omohyoid neck dissection. Pathology confirmed an intermediate-grade mucoepidermoid carcinoma that was confined to the submandibular gland. After 3 years of close follow-up, he had no further evidence of disease. Author comment: "[T]he chemotherapy seems to have been an important factor influencing the risk of the [second malignant neoplasm] in our case." Woo H-J, et al. Mucoepidermoid carcinoma of the submandibular gland after chemotherapy in a child. Auris Nasus Larynx 36: 244-246, No. 2, Apr 2009 - South Korea 801146058 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of mucoepidermoid carcinoma associated with busulfan or dexamethasone. The WHO ADR database contained one report of mucoepidermoid carcinoma (MedDRA) associated with dexamethasone, but none associated with busulfan. 1 Reactions 20 Jun 2009 No. 1257 0114-9954/10/1257-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1257 - 20 Jun 2009
★ SAntineoplastics
Mucoepidermoid carcinoma (first report withbusulfan and dexamethasone) as a secondarycancer: case report
An adolescent boy developed a secondarymucoepidermoid carcinoma of the submandibular gland,after receiving treatment with multiple antineoplastics foracute myeloid leukaemia.
After the initial diagnosis at age 5 years, the boy wasadministered the DCTER regimen, consisting of etoposide(cumulative dose 1600 mg/m2), dexamethasone,cytarabine, tioguanine and daunorubicin [dosages notstated]. He later received cyclophosphamide (cumulativedose 120 mg/kg) and busulfan [dosage not stated], beforeundergoing a stem cell transplant. He achieved completeremission. Eight years after his initial diagnosis, hepresented with a slow-growing, painless mass(1.5 × 2.0cm) in the left submandibular area. The mass wasmobile with a smooth surface and a hard consistency. Fine-needle aspiration cytology revealed a mucoepidermoidcarcinoma, and PET-CT scanning ruled out metastases. Hewas asymptomatic.
The boy underwent a left submandibular gland excisionand a left supra-omohyoid neck dissection. Pathologyconfirmed an intermediate-grade mucoepidermoidcarcinoma that was confined to the submandibular gland.After 3 years of close follow-up, he had no further evidenceof disease.
Author comment: "[T]he chemotherapy seems to havebeen an important factor influencing the risk of the [secondmalignant neoplasm] in our case."Woo H-J, et al. Mucoepidermoid carcinoma of the submandibular gland afterchemotherapy in a child. Auris Nasus Larynx 36: 244-246, No. 2, Apr 2009 -South Korea 801146058
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports ofmucoepidermoid carcinoma associated with busulfan ordexamethasone. The WHO ADR database contained onereport of mucoepidermoid carcinoma (MedDRA) associatedwith dexamethasone, but none associated with busulfan.
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Reactions 20 Jun 2009 No. 12570114-9954/10/1257-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
