Antineoplastics
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Reactions 1353 - 28 May 2011 Antineoplastics Neutropenia and herpes zoster: 2 case reports Two women with breast cancer developed neutropenia and herpes zoster during treatment with FAC (cyclophosphamide, doxorubicin [adriamycin] and fluorouracil) ± docetaxel [routes, dosages and durations of therapy to reactions onset not stated]. A 68-year-old postmenopausal woman began receiving chemotherapy according to the FAC regimen. After 4 cycles, she presented with a fever. She had a WBC count of 1.2 × 10 3 /mL, with a neutrophil count of 0.3 × 10 3 /mL and a lymphocyte count of 0.6 × 10 3 /mL. She was treated with amikacin, ceftazidime and filgrastim. Two days after starting filgrastim, she developed painful erythematous lesions on the right side of her body. A diagnosis of herpes zoster was made, and aciclovir was added to her treatment regimen. Her neutrophil and lymphocyte counts normalised after 4 days of filgrastim administration, with resolution of the lesions within 2 weeks. A 43-year-old premenopausal woman began receiving docetaxel after 4 cycles of FAC chemotherapy. After the first cycle of docetaxel, she developed neutropenia. Prophylactic filgrastim was started after the second cycle of docetaxel. She developed painful erythematous and vesicular lesions 3 days after starting filgrastim, and herpes zoster was diagnosed. Her WBC, neutrophil and lymphocyte counts were normal. Lidocaine was applied to the lesions for 1 week, and they resolved within 2 weeks. Sayin M, et al. Filgrastim helps to heal herpes zoster faster: Two case reports. Tumori 97: 123-125, No. 1, Jan-Feb 2011. Available from: URL: http:// dx.doi.org/10.1700/611.7150 - Turkey 803054400 1 Reactions 28 May 2011 No. 1353 0114-9954/10/1353-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Antineoplastics
Reactions 1353 - 28 May 2011
Antineoplastics
Neutropenia and herpes zoster: 2 case reportsTwo women with breast cancer developed neutropenia
and herpes zoster during treatment with FAC(cyclophosphamide, doxorubicin [adriamycin] andfluorouracil) ± docetaxel [routes, dosages and durations oftherapy to reactions onset not stated].
A 68-year-old postmenopausal woman began receivingchemotherapy according to the FAC regimen. After4 cycles, she presented with a fever. She had a WBC countof 1.2 × 103/mL, with a neutrophil count of 0.3 × 103/mLand a lymphocyte count of 0.6 × 103/mL. She was treatedwith amikacin, ceftazidime and filgrastim. Two days afterstarting filgrastim, she developed painful erythematouslesions on the right side of her body. A diagnosis of herpeszoster was made, and aciclovir was added to her treatmentregimen. Her neutrophil and lymphocyte countsnormalised after 4 days of filgrastim administration, withresolution of the lesions within 2 weeks.
A 43-year-old premenopausal woman began receivingdocetaxel after 4 cycles of FAC chemotherapy. After thefirst cycle of docetaxel, she developed neutropenia.Prophylactic filgrastim was started after the second cycle ofdocetaxel. She developed painful erythematous andvesicular lesions 3 days after starting filgrastim, and herpeszoster was diagnosed. Her WBC, neutrophil andlymphocyte counts were normal. Lidocaine was applied tothe lesions for 1 week, and they resolved within 2 weeks.Sayin M, et al. Filgrastim helps to heal herpes zoster faster: Two case reports.Tumori 97: 123-125, No. 1, Jan-Feb 2011. Available from: URL: http://dx.doi.org/10.1700/611.7150 - Turkey 803054400
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Reactions 28 May 2011 No. 13530114-9954/10/1353-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
