Antineoplastics
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Reactions 1160 - 14 Jul 2007 S Antineoplastics Thrombotic microangiopathy: case report A 31-year-old woman with Hodgkin’s disease developed thrombotic microangiopathy during treatment with antineoplastics [specific drugs, dosages and duration of treatment not stated]. The woman, who had previously received eight cycles of antineoplastic therapy [specific drugs, dosages and duration of treatment not stated], started receiving high-dose antineoplastic therapy and autologous stem cell transplantation. Six months after autologous bone marrow transplantation, she developed blurred vision, dyspnoea and a temperature between 38 and 38.5°C [time to reaction onset not stated]. Ophthalmogical examination showed severe loss of vision with a visual acuity of 20/400 in both eyes. Dilated fundus examination revealed bilateral cotton-wool spots around her peripapillary area. She had bilateral scattered retinal haemorrhages and markedly reduced retinal arterioles. She also had a cherry-red spot in her right eye. She was initially diagnosed with a Purtscher-like retinopathy. Laboratory investigations revealed severe anaemia (haemoglobin 6 g/dL), thrombocytopenia (platelet count 50 000 × 10 9 /L) and an elevated C-reactive protein levels (197). A chest x-ray revealed bilateral consolidation of her lower lobes and renal biopsy findings were consistent with thrombotic microangiopathy. She was provisionally diagnosed with systemic vasculitis. The woman received IV methylprednisolone and her nephropathy and retinopathy appeared to stop progressing. A work-up for vasculitis was negative and it was concluded that clinical and biological findings supported a diagnosis of thrombotic microangiopathy. [Patient outcome not clearly stated.] Parc C. Purtscher-like retinopathy as an initial presentation of a thrombotic microangiopathy associated with antineoplastic therapy. American Journal of Hematology 82: 486-488, No. 6, Jun 2007 - France 801078832 1 Reactions 14 Jul 2007 No. 1160 0114-9954/10/1160-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1160 - 14 Jul 2007
SAntineoplastics
Thrombotic microangiopathy: case reportA 31-year-old woman with Hodgkin’s disease developed
thrombotic microangiopathy during treatment withantineoplastics [specific drugs, dosages and duration oftreatment not stated].
The woman, who had previously received eight cycles ofantineoplastic therapy [specific drugs, dosages and duration oftreatment not stated], started receiving high-doseantineoplastic therapy and autologous stem celltransplantation. Six months after autologous bone marrowtransplantation, she developed blurred vision, dyspnoea and atemperature between 38 and 38.5°C [time to reaction onsetnot stated]. Ophthalmogical examination showed severe lossof vision with a visual acuity of 20/400 in both eyes. Dilatedfundus examination revealed bilateral cotton-wool spotsaround her peripapillary area. She had bilateral scatteredretinal haemorrhages and markedly reduced retinal arterioles.She also had a cherry-red spot in her right eye. She was initiallydiagnosed with a Purtscher-like retinopathy. Laboratoryinvestigations revealed severe anaemia (haemoglobin 6 g/dL),thrombocytopenia (platelet count 50 000 × 109/L) and anelevated C-reactive protein levels (197). A chest x-ray revealedbilateral consolidation of her lower lobes and renal biopsyfindings were consistent with thrombotic microangiopathy.She was provisionally diagnosed with systemic vasculitis.
The woman received IV methylprednisolone and hernephropathy and retinopathy appeared to stop progressing. Awork-up for vasculitis was negative and it was concluded thatclinical and biological findings supported a diagnosis ofthrombotic microangiopathy. [Patient outcome not clearlystated.]Parc C. Purtscher-like retinopathy as an initial presentation of a thromboticmicroangiopathy associated with antineoplastic therapy. American Journal ofHematology 82: 486-488, No. 6, Jun 2007 - France 801078832
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Reactions 14 Jul 2007 No. 11600114-9954/10/1160-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
