Antineoplastics
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Reactions 1219 - 13 Sep 2008 S Antineoplastics Human polyomavirus-associated neurological disorders: case report A 46-year-old man developed human polyomavirus (BK virus)-associated neurological symptoms after receiving CHOP-R 14 chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone or prednisolone, * and rituximab) and methotrexate [duration of treatments to reaction onset not clearly stated]. The man was diagnosed with diffuse large B-cell lymphoma and received four courses of CHOP-R 14 chemotherapy [dosages not stated] with intrathecal methotrexate 12mg [frequency not stated] for CNS chemo-prophylaxis. He developed diplopia, recurrent headache and tinnitus 10 days after chemotherapy completion. On admission 2 months after lymphoma diagnosis, a neurological examination revealed bilateral sixth cranial nerve impairment and CSF analysis disclosed human polyomavirus at 100 copies/mL; human polyomavirus was also found in his urine (53 541 copies/mL). The viral count had decreased to 3877 copies/mL of urine on repeat test 22 days later, and he showed clinical improvement. Symptoms completely resolved 6 days later; at that time, CSF analysis was negative for human polyomavirus. Urine samples were negative about 2 weeks later. Author comment: "The self-limiting course of the neurologic complication was likely to be related to the short- term and low-level immunosuppression, possibly allowing the recovery of anti-viral specific immune responses." * It was not stated whether the patient was receiving prednisone or prednisolone. Ferrari A, et al. BK virus infection and neurologic dysfunctions in a patient with lymphoma treated with chemotherapy and rituximab. European Journal of Haematology 81: 244-245, No. 3, Sep 2008 - Italy 801117834 1 Reactions 13 Sep 2008 No. 1219 0114-9954/10/1219-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1219 - 13 Sep 2008
SAntineoplastics
Human polyomavirus-associated neurologicaldisorders: case report
A 46-year-old man developed human polyomavirus (BKvirus)-associated neurological symptoms after receivingCHOP-R 14 chemotherapy (cyclophosphamide, doxorubicin,vincristine, prednisone or prednisolone,* and rituximab) andmethotrexate [duration of treatments to reaction onset notclearly stated].
The man was diagnosed with diffuse large B-cell lymphomaand received four courses of CHOP-R 14 chemotherapy[dosages not stated] with intrathecal methotrexate 12mg[frequency not stated] for CNS chemo-prophylaxis. Hedeveloped diplopia, recurrent headache and tinnitus 10 daysafter chemotherapy completion. On admission 2 months afterlymphoma diagnosis, a neurological examination revealedbilateral sixth cranial nerve impairment and CSF analysisdisclosed human polyomavirus at 100 copies/mL; humanpolyomavirus was also found in his urine (53 541 copies/mL).The viral count had decreased to 3877 copies/mL of urine onrepeat test 22 days later, and he showed clinical improvement.Symptoms completely resolved 6 days later; at that time, CSFanalysis was negative for human polyomavirus. Urine sampleswere negative about 2 weeks later.
Author comment: "The self-limiting course of theneurologic complication was likely to be related to the short-term and low-level immunosuppression, possibly allowingthe recovery of anti-viral specific immune responses."
* It was not stated whether the patient was receiving prednisone orprednisolone.
Ferrari A, et al. BK virus infection and neurologic dysfunctions in a patient withlymphoma treated with chemotherapy and rituximab. European Journal ofHaematology 81: 244-245, No. 3, Sep 2008 - Italy 801117834
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Reactions 13 Sep 2008 No. 12190114-9954/10/1219-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
