Antineoplastics
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Reactions 1255 - 6 Jun 2009 S Antineoplastics Paroxysmal atrial fibrillation in an elderly patient: case report A 75-year-old man diagnosed with acanthosis nigricans and stage IV gastric adenocarcinoma, began palliative chemotherapy according to the PELF program. The regimen included cisplatin, epirubicin, folinic acid [leucovorin] and fluorouracil [dosages not stated]. He received four cycles. No further cancer progression was observed; however, paroxysmal atrial fibrillation occurred during treatment [duration of therapy to reaction onset not stated]. The treatment was discontinued due to decreased exercise tolerance and concerns over the cardiotoxicity of the treatment. He was directed to further symptomatic and palliative care; he died 4 months after the completion of treatment. Krawczyk M, et al. Acanthosis nigricans as a paraneoplastic syndrome: case reports and review of literature. Polskie Archiwum Medycyny Wewnetrznej 119: 180-183, No. 3, 2009 - Poland 801141587 » Editorial comment: The authors also reported on a further case where a patient was receiving cisplatin, epirubicin, folinic acid and fluorouracil but no adverse drug reaction developed. 1 Reactions 6 Jun 2009 No. 1255 0114-9954/10/1255-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1255 - 6 Jun 2009
SAntineoplastics
Paroxysmal atrial fibrillation in an elderly patient:case report
A 75-year-old man diagnosed with acanthosis nigricansand stage IV gastric adenocarcinoma, began palliativechemotherapy according to the PELF program. The regimenincluded cisplatin, epirubicin, folinic acid [leucovorin] andfluorouracil [dosages not stated]. He received four cycles.No further cancer progression was observed; however,paroxysmal atrial fibrillation occurred during treatment[duration of therapy to reaction onset not stated]. Thetreatment was discontinued due to decreased exercisetolerance and concerns over the cardiotoxicity of thetreatment. He was directed to further symptomatic andpalliative care; he died 4 months after the completion oftreatment.Krawczyk M, et al. Acanthosis nigricans as a paraneoplastic syndrome: casereports and review of literature. Polskie Archiwum Medycyny Wewnetrznej 119:180-183, No. 3, 2009 - Poland 801141587
» Editorial comment: The authors also reported on afurther case where a patient was receiving cisplatin,epirubicin, folinic acid and fluorouracil but no adverse drugreaction developed.
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Reactions 6 Jun 2009 No. 12550114-9954/10/1255-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
