Antineoplastics
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Reactions 1119 - 16 Sep 2006 S Antineoplastics Chondrosarcoma: case report A 37-year-old man developed chondrosarcoma as a malignant transformation of his residual teratoma after receiving chemotherapy with cisplatin, bleomycin, etoposide and ifosfamide for testicular cancer. The man received four cycles of cisplatin 40 mg/m 2 , etoposide 120 mg/m 2 and bleomycin 15 mg over 3 days every 3 weeks; before chemotherapy initiation, an abdominal CT scan showed two para-aortic lymph nodes with maximal diameters of 2.2 and 1.6cm, respectively. One month after chemotherapy completion, an abdominal CT scan revealed an increase in the size of his para-aortic lymph node to 2.8cm. He received two additional cycles of cisplatin 20 mg/m 2 , etoposide 75 mg/m 2 and ifosfamide 1200 mg/m 2 over 5 days, and 1 month later, a CT scan showed that his para-aortic lymph node had not been diminished. The man underwent a retroperitoneal resection of his whole, macroscopically evident residual mass; histological analyses of his resected mass showed mature teratoma. After 3 months, a CT scan revealed 1.6cm long strapped para-aortic lymph node elements. His retroperitoneal mass continued to increase in size and, 26 months postsurgery, his retroperitoneal mass had increased to 2.5cm; during this time, no increase in his serum tumour markers was recorded. He then underwent the resection of his recurrent retroperitoneal mass. Histological analyses showed teratoma with malignant transformation into chondrosarcoma. Author comment: "Non-germ cell malignancies may originate from the chemotherapy-induced differentiation of the totipotential germ cell (embryonal cell) component of the tumor with concomitant malignant transformation or from transformation of the teratomatous elements." Assimakopoulos SF, et al. A case of chondrosarcoma developing in a recurrent retroperitoneal mass after chemotherapy for testicular germ cell tumor. Urologia Internationalis 77: 86-88, No. 1, 2006 - Greece 801044335 1 Reactions 16 Sep 2006 No. 1119 0114-9954/10/1119-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1119 - 16 Sep 2006
SAntineoplastics
Chondrosarcoma: case reportA 37-year-old man developed chondrosarcoma as a
malignant transformation of his residual teratoma afterreceiving chemotherapy with cisplatin, bleomycin, etoposideand ifosfamide for testicular cancer.
The man received four cycles of cisplatin 40 mg/m2,etoposide 120 mg/m2 and bleomycin 15 mg over 3 days every3 weeks; before chemotherapy initiation, an abdominalCT scan showed two para-aortic lymph nodes with maximaldiameters of 2.2 and 1.6cm, respectively. One month afterchemotherapy completion, an abdominal CT scan revealed anincrease in the size of his para-aortic lymph node to 2.8cm. Hereceived two additional cycles of cisplatin 20 mg/m2,etoposide 75 mg/m2 and ifosfamide 1200 mg/m2 over 5 days,and 1 month later, a CT scan showed that his para-aorticlymph node had not been diminished.
The man underwent a retroperitoneal resection of hiswhole, macroscopically evident residual mass; histologicalanalyses of his resected mass showed mature teratoma. After3 months, a CT scan revealed 1.6cm long strapped para-aorticlymph node elements. His retroperitoneal mass continued toincrease in size and, 26 months postsurgery, hisretroperitoneal mass had increased to 2.5cm; during this time,no increase in his serum tumour markers was recorded. Hethen underwent the resection of his recurrent retroperitonealmass. Histological analyses showed teratoma with malignanttransformation into chondrosarcoma.
Author comment: "Non-germ cell malignancies mayoriginate from the chemotherapy-induced differentiation ofthe totipotential germ cell (embryonal cell) component of thetumor with concomitant malignant transformation or fromtransformation of the teratomatous elements."Assimakopoulos SF, et al. A case of chondrosarcoma developing in a recurrentretroperitoneal mass after chemotherapy for testicular germ cell tumor. UrologiaInternationalis 77: 86-88, No. 1, 2006 - Greece 801044335
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Reactions 16 Sep 2006 No. 11190114-9954/10/1119-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
