Antineoplastics
1
Reactions 1473, p6-7 - 12 Oct 2013 S Antineoplastics Bone marrow suppression in elderly patients: 2 case reports Two elderly men developed bone marrow suppression during chemotherapy with cyclophosphamide, vincristine, prednisone, doxorubicin, and etoposide for Langerhan’s cell histiocytosis [routes not stated]. An elderly man [age at reaction onset not clearly stated] underwent chemotherapy with a 21-day cycle of cyclophosphamide (750 mg/m 2 , d1), vincristine (1.4 mg/m 2 , d1), and prednisone (100 mg/m 2 , d1–5). He received six cycles. After completion of his chemotherapy, he developed CTCAE grade IV bone marrow suppression. He was treated with a blood transfusion and G-CSF to increase his white blood cell count. He had a relapse of Langerhan’s cell histiocytosis and received further chemotherapy with etoposide (100mg, d1–3), cyclophosphamide (750 mg/m 2 , d1), doxorubicin (50 mg/m 2 , d1), vincristine (1.4 mg/m 2 , d1), and prednisone (100mg, d1–5). He experienced grade IV bone marrow suppression after one cycle. He underwent a blood transfusion and treatment to increase his white blood cell count. His total survival period was 23 months [outcome of ADR not clearly stated]. A 66-year-old man underwent chemotherapy with cyclophosphamide, vincristine, and prednisone for four cycles [dosages not stated]. Partial remission was achieved and he underwent radiotherapy. He underwent further chemotherapy with cyclophosphamide, vincristine, and prednisone and developed grade IV bone marrow suppression after two cycles. He received a blood transfusion and treatment to increase his white blood cell count. He gradually recovered. His total survival period was 26 months [outcome of ADR not clearly stated]. Author comment: The main side effect of radiotherapy and/or chemotherapy is bone marrow suppression after the treatment. Zhang X, et al. Experience on the clinical features and treatment of elderly Langerhans cell histiocytosis. Journal of Dalian Medical University 35: 163-166, No. 2, 2013. Available from: URL: http://dx.doi.org/10.11724/jdmu.2013.02.17 [Chinese; summarised from a translation] - China 803093810 » Editorial comment: This paper included a third man with Langerhan’s cell histiocytosis but this patient did not receive chemotherapy. 1 Reactions 12 Oct 2013 No. 1473 0114-9954/13/1473-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1473, p6-7 - 12 Oct 2013
SAntineoplastics
Bone marrow suppression in elderly patients:2 case reports
Two elderly men developed bone marrow suppressionduring chemotherapy with cyclophosphamide, vincristine,prednisone, doxorubicin, and etoposide for Langerhan’s cellhistiocytosis [routes not stated].
An elderly man [age at reaction onset not clearly stated]underwent chemotherapy with a 21-day cycle ofcyclophosphamide (750 mg/m2, d1), vincristine (1.4 mg/m2,d1), and prednisone (100 mg/m2, d1–5). He received sixcycles. After completion of his chemotherapy, he developedCTCAE grade IV bone marrow suppression. He was treatedwith a blood transfusion and G-CSF to increase his white bloodcell count. He had a relapse of Langerhan’s cell histiocytosisand received further chemotherapy with etoposide (100mg,d1–3), cyclophosphamide (750 mg/m2, d1), doxorubicin(50 mg/m2, d1), vincristine (1.4 mg/m2, d1), and prednisone(100mg, d1–5). He experienced grade IV bone marrowsuppression after one cycle. He underwent a blood transfusionand treatment to increase his white blood cell count. His totalsurvival period was 23 months [outcome of ADR not clearlystated].
A 66-year-old man underwent chemotherapy withcyclophosphamide, vincristine, and prednisone for four cycles[dosages not stated]. Partial remission was achieved and heunderwent radiotherapy. He underwent further chemotherapywith cyclophosphamide, vincristine, and prednisone anddeveloped grade IV bone marrow suppression after twocycles. He received a blood transfusion and treatment toincrease his white blood cell count. He gradually recovered.His total survival period was 26 months [outcome of ADR notclearly stated].
Author comment: The main side effect of radiotherapyand/or chemotherapy is bone marrow suppression after thetreatment.Zhang X, et al. Experience on the clinical features and treatment of elderlyLangerhans cell histiocytosis. Journal of Dalian Medical University 35: 163-166,No. 2, 2013. Available from: URL: http://dx.doi.org/10.11724/jdmu.2013.02.17[Chinese; summarised from a translation] - China 803093810
» Editorial comment: This paper included a third man withLangerhan’s cell histiocytosis but this patient did not receivechemotherapy.
1
Reactions 12 Oct 2013 No. 14730114-9954/13/1473-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
